Lignan and isoflavone excretion in relation to uterine fibroids: a case-control study of young to middle-aged women in the United States

Charlotte Atkinson, Johanna W. Lampe, Delia Scholes, Chu Chen, Kristiina Wähälä, Stephen M. Schwartz
The American journal of clinical nutrition · 2006 · vol. 84(3) , pp. 587–593 · doi:10.1093/ajcn/84.3.587 · PMID:16960173 · W2120750523
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This case-control study investigated the relationship between lignan and isoflavone excretion and the presence of uterine fibroids in young to middle-aged women in the United States.

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Abstract

BACKGROUND: Uterine fibroids are hormonally responsive; estradiol and progesterone stimulate their growth, and gonadotrophin-releasing hormone agonists shrink them. Phytoestrogens, including isoflavones and lignans, can act as weak estrogens or antiestrogens. OBJECTIVE: The objective of this case-control study was to evaluate the relation between uterine fibroid risk and phytoestrogen exposure. DESIGN: Two overnight urine collections (48 h apart) from 170 uterine fibroid cases and 173 controls were analyzed for isoflavonoids (ie, daidzein, genistein, equol, and O-desmethylangolensin) and lignans (enterodiol and enterolactone). Logistic regression was used to determine associations between the mean excretion of the 2 collections and the risk of uterine fibroids. RESULTS: Unadjusted isoflavone excretion did not differ significantly between cases and controls (2.33 +/- 5.82 and 2.60 +/- 5.90 nmol/mg Cr, respectively; P = 0.68), but cases excreted significantly less lignans than did controls (2.86 +/- 3.45 and 4.57 +/- 6.67 nmol/mg Cr, respectively; P < 0.01). The trend for a reduced risk of uterine fibroids with increasing quartiles of lignan excretion was significant (odds ratio for highest versus lowest quartile = 0.31; 95% CI: 0.17, 0.58; P for trend < 0.01). When adjusted for age, BMI, race, family history of uterine fibroids, and isoflavone excretion, this trend remained but was attenuated (P = 0.07). CONCLUSIONS: Our findings suggest a modest inverse association between lignan excretion and uterine fibroid risk. Whether this relation represents an effect of lignans per se or of other constituents of lignan-containing foods on the development of uterine fibroids remains to be determined. No association was found between isoflavone excretion and uterine fibroids; however, the intake of soy foods, the primary source of isoflavones, was low in this population.

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MeSH descriptors

Glycine max Glycine max Isoflavones Leiomyoma Lignans Adult Biomarkers Biomarkers Case-Control Studies Confidence Intervals Female Humans Isoflavones Leiomyoma Leiomyoma Lignans Linear Models Middle Aged Odds Ratio Phytoestrogens

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