Antioxidant enzymes in women with endometrial polyps: relation with sex hormones

Snežana A Pejić, Snežana Pejić, Jelena D Kasapović, Jelena Kasapović, Ana U Todorović, Ana Todorović, Vesna Stojiljković, Vesna R Stojiljković, Ljubica V Gavrilović, Ljubica Gavrilović, Nataša M Popović, Nataša Popović, Snežana B. Pajović
European journal of obstetrics, gynecology, and reproductive biology · 2013 · vol. 170(1) , pp. 241–246 · doi:10.1016/j.ejogrb.2013.06.024 · PMID:23871381 · W2015149730
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This study found that antioxidant enzyme activities and lipid hydroperoxide levels in women with endometrial polyps are influenced by sex hormone levels during the menstrual cycle and postmenopause.

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Abstract

OBJECTIVE: To investigate whether antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones (estradiol, progesterone, FSH, and LH) during the menstrual cycle and in postmenopause. STUDY DESIGN: The material consisted of blood and endometrial tissue specimens from women diagnosed with endometrial polyps. Patients were divided into groups depending on the phase of the menstrual cycle--follicular or luteal--and the postmenopause. The activities of antioxidant enzymes and the lipid hydroperoxide levels were compared among the phases and a linear regression model was used to evaluate the associations between hormones and antioxidant/oxidant variables. RESULTS: In the blood of examined women, a significant difference in superoxide dismutase activity and lipid hydroperoxide levels was recorded among the phases. There was also a positive correlation between the estradiol concentration and superoxide dismutase. In polyp tissue, we recorded a phase-related difference in superoxide dismutase and glutathione peroxidase activities as well as in the lipid hydroperoxide levels. A negative correlation was observed between FSH/LH and glutathione peroxidase, and between LH and superoxide dismutase. CONCLUSION: Antioxidant enzymes and lipid hydroperoxide levels in patients with endometrial polyps are influenced by the changes in sex hormones during the menstrual cycle and after the menopause, pointing to a role of the observed relationship in polyp etiology.

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MeSH descriptors

Antioxidants Gonadal Steroid Hormones Gonadotropins, Pituitary Menstrual Cycle Polyps Uterine Diseases Adult Antioxidants Female Gonadal Steroid Hormones Gonadotropins, Pituitary Humans Linear Models Lipid Peroxidation Menstrual Cycle Polyps Polyps Postmenopause Uterine Diseases Uterine Diseases

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