Serum and peritoneal lavage fluid CA-125 levels in endometriosis

R W Moretuzzo, Moretuzzo RW, Dilauro S, S DiLauro, E Jenison, Jenison E, Chen SL, S L Chen, R H Reindollar, Reindollar RH, P G McDonough, McDonough PG
Fertility and sterility · 1988 · vol. 50(3) , pp. 430–3 · doi:10.1016/s0015-0282(16)60127-9 · PMID:2457518
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This study compared serum and peritoneal lavage fluid CA-125 levels in women with endometriosis versus controls, finding that serum CA-125 was significantly elevated and served as a more sensitive indicator of the disease.

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Abstract

Serum and peritoneal lavage fluid CA-125 levels were assayed in 20 women with endometriosis and 20 control women at the time of laparoscopy. Serum levels of CA-125 were significantly higher in women with endometriosis. Peritoneal lavage fluid CA-125 levels were significantly higher than serum levels but showed no significant difference between control and endometriosis patients. Peritoneal lavage fluid CA-125 did not follow expected dilution curves when attempts were made to validate the assay. Serum CA-125 levels were a more sensitive indicator of endometriosis, than peritoneal lavage fluid CA-125 levels.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Neoplasm Endometriosis Peritoneal Lavage Peritoneal Lavage Adult Adult Antigens, Neoplasm Antigens, Neoplasm Antigens, Surface Antigens, Surface Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Epitopes Epitopes Female Female Humans Humans

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europepmc
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pubmed
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Courtesy of the U.S. National Library of Medicine