Multifunctional alpha-enolase: its role in diseases

Pancholi V, V Pancholi
Cellular and molecular life sciences : CMLS · 2001 · vol. 58(7) , pp. 902–20 · doi:10.1007/pl00000910 · PMID:11497239 · PMC11337373
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This review describes alpha-enolase as a multifunctional protein that functions as a plasminogen receptor, heat-shock protein, and chromatin binder, playing crucial roles in fibrinolysis and pathophysiological processes in various diseases.

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This review article examines the multifunctional nature of alpha-enolase, a glycolytic enzyme that functions as a surface protein on hematopoietic, epithelial, and endothelial cells. The text highlights its role as a plasminogen receptor in fibrinolysis, its capacity to act as a heat-shock protein, and its involvement in transcription and autoimmune disorders such as rheumatic fever and systemic lupus erythematosus. No specific clinical limitations or caveats are explicitly detailed within the provided abstract. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Enolase, a key glycolytic enzyme, belongs to a novel class of surface proteins which do not possess classical machinery for surface transport, yet through an unknown mechanism are transported on the cell surface. Enolase is a multifunctional protein, and its ability to serve as a plasminogen receptor on the surface of a variety of hematopoetic, epithelial and endothelial cells suggests that it may play an important role in the intravascular and pericellular fibrinolytic system. Its role in systemic and invasive autoimmune disorders was recognized only very recently. In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes.
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Abstract. Enolase, a key glycolytic enzyme, belongs to a novel class of surface proteins which do not possess classical machinery for surface transport, yet through an unknown mechanism are transported on the cell surface. Enolase is a multifunctional protein, and its ability to serve as a plasminogen receptor on the surface of a variety of hematopoetic, epithelial and endothelial cells suggests that it may play an important role in the intravascular and pericellular fibrinolytic system. Its role in systemic and invasive autoimmune disorders was recognized only very recently. In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes. Keywords: Key words.Enolase; autoimmunity; rheumatic fever; SLE. Footnotes Received 6 December 2000; received after revision 24 January 2001; accepted 26 January 2001

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Phosphopyruvate Hydratase Amino Acid Sequence Animals Disease Humans Molecular Sequence Data Phosphopyruvate Hydratase Phosphopyruvate Hydratase Phosphopyruvate Hydratase

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