Tumor necrosis factor-alpha-induced cyclooxygenase-2 overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation

Young Ah Kim, Kim YA, Ji Yeon Kim, Kim JY, Kim MR, Mee‐Ran Kim, Mi Ran Kim, Hwang KJ, Kyung Joo Hwang, Doo Young Chang, Chang DY, Myung Kwon Jeon, Jeon MK
The Journal of reproductive medicine · 2009 · vol. 54(10) , pp. 625–30 · PMID:20677482 · W127401376
Lab / animal OA: closed CC0 ⤵ 11 in-corpus citations
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TNF-alpha induces COX-2 overexpression in eutopic endometrial stromal cells from women with endometriosis via NF-kappaB activation, with a greater induction observed compared to women without endometriosis.

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Abstract

OBJECTIVE: To investigate the role of NF-kappaB during the induction of COX-2 by TNF-alpha in the eutopic endometrium of women with and without endometriosis using stromal cell culture. STUDY DESIGN: Experimental study in cultured stromal cells of the eutopic endometrium of women with and without endometriosis in the presence of TNF-alpha. RESULTS: Within 5-20 minutes of stimulation with TNF-alpha, p-IkappaB was clearly observed in the eutopic endometrium of women with endometriosis and in that of women without endometriosis. COX-2 protein was significantly induced by treatment with TNF-alpha in both eutopic endometrial stromal cells of women with and without endometriosis (p < 0.05), but the degree of induction was significantly increased in eutopic endometrial stromal cells of women with endometriosis than those of women without endometriosis (p < 0.05). CONCLUSION: Overexpression of COX-2 by TNF-alpha in the eutopic endometrium of women with endometriosis may play a critical role in such pathophysiologic processes as endometriosis formation.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis NF-kappa B Stromal Cells Tumor Necrosis Factor-alpha Adult Adult Cells, Cultured Cells, Cultured Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Humans

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