Venlafaxine-associated vaginal bleeding

Sunny A. Linnebur, Joseph J. Saseen, Wilson D. Pace
Pharmacotherapy · 2002 · vol. 22(5) , pp. 652–655 · doi:10.1592/phco.22.8.652.33219 · PMID:12013367 · W2124806056
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A case report describes venlafaxine-associated vaginal bleeding in a 41-year-old woman, supporting surveillance data that the antidepressant may cause this adverse effect.

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Abstract

A 41-year-old amenorrheic woman started taking venlafaxine 37.5 mg/day for treatment of depression; 7 days later, she experienced vaginal bleeding, which ceased 1 day after she stopped taking the drug. On rechallenge with venlafaxine, she again experienced vaginal bleeding that resolved after discontinuation. We found no published reports describing vaginal bleeding associated with venlafaxine. However, premarketing and postmarketing data report similar adverse effects in patients taking the agent. In addition, several cases of menstrual irregularities have occurred with two other antidepressants: fluoxetine and bupropion. This case report supports previous surveillance data indicating that venlafaxine may cause vaginal bleeding.

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MeSH descriptors

Antidepressive Agents, Second-Generation Cyclohexanols Hemorrhage Vaginal Diseases Adult Antidepressive Agents, Second-Generation Antidepressive Agents, Second-Generation Cyclohexanols Cyclohexanols Depressive Disorder Depressive Disorder Depressive Disorder Female Hemorrhage Humans Menstruation Menstruation Vaginal Diseases Venlafaxine Hydrochloride

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License: CC0 · commercial use OK