Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility

Małgorzata Szczepańska, Szczepańska M, Przemyslaw Wirstlein, Wirstlein P, Przemysław Wirstlein, Małgorzata Zawadzka, Ewa Wender-Ożegowska, Wender-Ożegowska E, Paweł P. Jagodziński, Jagodziński PP, Paweł P. Jagodzińśki
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2018 · vol. 34(12) , pp. 1084–1090 · doi:10.1080/09513590.2018.1490403 · PMID:30130982 · W2888581931
Other OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Endometrial TET1 and TET2 expression was reduced in women with endometriosis-associated infertility, while TET3 expression increased from the follicular to luteal phase in these women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Little is known about the differences in ten-eleven translocation 1, 2, and 3 (TET1-3) expression in the endometrial phases in eutopic endometrium from infertile women with endometriosis (IWE) and fertile women without endometriosis (FW). Using RT-qPCR and western blot analysis, we assessed the TET expression in the mid-follicular and mid-luteal phases in eutopic endometrium from IWE (n = 38) and FW (n = 18). Both IWE and FW underwent laparoscopic and histological examinations for endometriosis. In the mid-luteal eutopic endometrium in IWE, compared to that of FW, we found significantly reduced levels of TET1 transcripts and proteins (p = .001 and p = .003, respectively) at the severity stage of I/II (p = .029 and p = .003, respectively) and transcripts only at the severity stage of III/IV (p = .003). In the mid-follicular eutopic endometrium of IWE, compared to that of FW, there was a statistically significant reduction in TET2 transcript levels at the severity stage of III/IV (p = .037). Compared to the mid-follicular endometrium, we found a statistically significant increase in TET3 transcript levels during the mid-luteal phase in the eutopic endometrium of all IWE (p = .034) and in the severity stage of III/IV (p = .025). We observed a change in the expression levels of TET1-3 in the eutopic endometrium of IWE.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Dioxygenases DNA-Binding Proteins Endometriosis Infertility, Female Mixed Function Oxygenases Proto-Oncogene Proteins Case-Control Studies Case-Control Studies Dioxygenases Dioxygenases DNA-Binding Proteins DNA-Binding Proteins Endometriosis Endometriosis Endometriosis Female Female Humans Humans Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (11)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:22:53.024375+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK