Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma

Ali Yavuzcan, Mete Cağlar, Mete Çağlar, Yusuf Ustün, Yusuf Üstün, Serdar Dilbaz, Ismail Ozdemir, İsmail Özdemir, Elif Yıldız, Atilla Ozkara, Atilla Özkara, Selahattin Kumru
Journal of the Turkish German Gynecological Association · 2013 · vol. 14(4) , pp. 210–215 · doi:10.5152/jtgga.2013.55452 · PMID:24592108 · W1975256272
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Mean platelet volume, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio were not useful for preoperative differentiation of advanced endometriosis with endometrioma versus other adnexal masses.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The study compared preoperative mean platelet volume and systemic inflammatory response markers—neutrophil/lymphocyte ratio and platelet/lymphocyte ratio—between women with advanced-stage (stage 3/4) endometriosis with endometrioma and women with non-endometrioma adnexal masses, using patients undergoing operations for infertility or an adnexal mass with preoperative blood measures before laparoscopic tubal ligation. Across groups, hemoglobin, leukocyte counts, platelet counts, neutrophil and lymphocyte counts, and the derived MPV, NLR, and PLR were not significantly different. Cancer antigen 125 (Ca-125) was significantly higher in the endometrioma group, but endometrioma size was significantly lower than in non-endometrioma masses. The paper concludes that MPV, NLR, and PLR are not useful preoperative markers for distinguishing advanced-stage endometriosis with endometrioma, and it specifically does not establish these markers as reflecting the reported severe inflammation at cellular or molecular levels. This paper is centrally about endometriosis—evaluating whether MPV, NLR, and PLR differ in advanced-stage endometriosis with endometrioma compared with other adnexal masses.

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Abstract

OBJECTIVE: We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis having endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA). MATERIAL AND METHODS: Patients who underwent operations with the pre-diagnosis of infertility or adnexal mass and who underwent laparoscopic tubal ligation were included. RESULTS: Haemoglobin levels, leucocyte count, platelet count, neutrophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively). Patients with stage 3/4 endometriosis having OMA, patients with non-OMA and control patients were also not significantly different in terms of MPV (p=0.836), neutrophil/lymphocyte ratio (NLR) (p=0.555) and platelet/lymphocyte ratio (PLR) (p=0.358). Preoperative cancer antigen 125 (Ca-125) levels were significantly higher in patients with OMA (p=0.006). Mean size of the OMAs was significantly lower than non-OMAs (p=0.000). CONCLUSION: It is very important to determine advanced stage endometriosis and OMAs during preoperative evaluation in order to inform patients and plan an appropriate surgical approach. We demonstrate that MPV, NLR and PLR values are not useful for this purpose in patients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level.
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Abstract

Objective: We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis having endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA).

Material and methods

Patients who underwent operations with the pre-diagnosis of infertility or adnexal mass and who underwent laparoscopic tubal ligation were included.

Results

Haemoglobin levels, leucocyte count, platelet count, neutrophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively). Patients with stage 3/4 endometriosis having OMA, patients with non-OMA and control patients were also not significantly different in terms of MPV (p=0.836), neutrophil/lymphocyte ratio (NLR) (p=0.555) and platelet/lymphocyte ratio (PLR) (p=0.358). Preoperative cancer antigen 125 (Ca-125) levels were significantly higher in patients with OMA (p=0.006). Mean size of the OMAs was significantly lower than non-OMAs (p=0.000).

Conclusion

It is very important to determine advanced stage endometriosis and OMAs during preoperative evaluation in order to inform patients and plan an appropriate surgical approach. We demonstrate that MPV, NLR and PLR values are not useful for this purpose in patients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level.

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endometriosisendometriomainfertility

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