Liver receptor homologue‐1 and steroidogenic factor‐1 expression in cultured granulosa cells from patients with endometriosis: A preliminary study

Xiang Lu, Xiang Lü, Zhengmu Wu, Zheng-mu Wu, Yong-wei Wang, Y.-X. Wang, Min Wang, Wei-wei Cheng, Weiwei Cheng
Journal of Obstetrics and Gynaecology Research · 2015 · vol. 41(12) , pp. 1927–1934 · doi:10.1111/jog.12832 · PMID:26530052 · W2126260157
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Granulosa cells from women with endometriosis showed decreased expression of LRH-1, SF-1, and CYP19 PII mRNA, with LRH-1 and SF-1 positively correlated with CYP19 PII.

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Abstract

AIM: The expression of aromatase (via CYP19 and the CYP19 PII promoter) and the orphan nuclear receptor family members, liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) in cultured luteinized granulosa cells from women with endometriosis were investigated. METHODS: Luteinized granulosa cells from patients undergoing in vitro fertilization (16 patients with endometriosis and 28 controls) were examined for messenger ribonucleic acid (mRNA) expression of CYP19, CYP19 PII, LRH-1 and SF-1, determined by quantitative reverse transcription-polymerase chain reaction. Student's t-test, the Mann-Whitney U test and Spearman's rank correlation were used for statistical analysis. RESULTS: The number of high quality embryos in the endometriosis group was significantly lower than in the control group. The mRNA expression levels of CYP19, CYP19 PII, LRH-1 and SF-1 in granulosa-lutein cells were decreased in women with endometriosis compared to the control group. The simultaneous down-regulation expression of LRH-1, SF-1 and CYP19 PII in endometriotic granulosa cells indicated their positive correlation. CONCLUSION: Our results demonstrate aberrant expressions of SF-1 and LRH-1 in endometriotic granulosa-lutein cells. This finding may be helpful in understanding infertility associated with endometriosis and reduced P450 aromatase activity in endometriotic granulosa cells.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Granulosa Cells Receptors, Cytoplasmic and Nuclear Steroidogenic Factor 1 Adult Aromatase Aromatase Cells, Cultured Endometriosis Female Granulosa Cells Humans Receptors, Cytoplasmic and Nuclear RNA, Messenger RNA, Messenger Steroidogenic Factor 1

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