Adenomyosis with extensive glandular proliferation simulating infiltrating malignancy on magnetic resonance imaging

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AI-generated summary by claude@2026-06+body, 2026-06-09

This case report describes multicystic adenomyosis that mimicked infiltrating malignancy on MRI, with the final diagnosis being adenomyosis coexisting with simple endometrial hyperplasia.

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This paper reports a single case of multicystic adenomyosis with extensive glandular proliferation, evaluated using preoperative magnetic resonance imaging (MRI) and positron emission tomography. The patient presented with an irregular menstrual cycle and abnormal genital bleeding that progressed to severe anemia, and MRI showed endometrial hyperplasia with a myometrial lesion featuring a high-signal multicystic mass, leading to a confusing preoperative diagnosis that simulated infiltrating malignancy. After hysterectomy, gross examination demonstrated villous endometrium and a thickened myometrium with multiple small cysts containing serous transparent fluid, and the final diagnosis was adenomyosis coexisting with simple endometrial hyperplasia. As a case report, the major limitation is that conclusions are based on one patient’s imaging and pathology findings. This paper is centrally about endometriosis and/or adenomyosis — specifically adenomyosis that can mimic malignancy on MRI.

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Abstract

We report a case of multicystic adenomyosis, which is an exceedingly rare benign tumor. The patient complained of an irregular menstrual cycle and abnormal genital bleeding that gradually increased in amount and frequency. The patient finally became severely anemic, and a hysterectomy was therefore performed. T2-weighted magnetic resonance imaging (MRI) indicated hyperplasia of the endometrium, with a myometrial lesion, where a high signal intensity multicystic mass was observed. The preoperative diagnosis was complicated by confusing MRI results. Postoperative macroscopic examination revealed a villous endometrium and a myometrium thickened with multiple small cysts containing serous transparent fluid. The final diagnosis, based on the hysterectomy specimen, was adenomyosis coexisting with simple endometrial hyperplasia. The MRI and positron emission tomography images are presented. Similar content being viewed by others

References

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Condition tags

mesh:D004715adenomyosis

MeSH descriptors

Endometriosis Magnetic Resonance Imaging Adult Diagnosis, Differential Endometriosis Endometriosis Endometriosis Female Humans Hysterectomy Magnetic Resonance Imaging Positron-Emission Tomography Uterine Neoplasms Uterine Neoplasms

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