Effect of a baseline ovarian cyst on the outcome of in vitro fertilization-embryo transfer

Shimon Segal, S Segal, Jan L. Shifren, J L Shifren, K B Isaacson, Keith Isaacson, Lucy Leykin, L Leykin, Y Chang, Yuchiao Chang, Lubna Pal, L Pal, Thomas L. Toth, T L Toth
Fertility and sterility · 1999 · vol. 71(2) , pp. 274–277 · doi:10.1016/s0015-0282(98)00449-x · PMID:9988397 · W2023155199
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This study investigated the impact of a baseline ovarian cyst on the success rates of in vitro fertilization–embryo transfer procedures.

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Abstract

OBJECTIVE: To determine the significance of prestimulation ovarian cysts on the response to controlled ovarian hyperstimulation and the outcome of IVF. DESIGN: Retrospective study. SETTING: In vitro fertilization unit in an academic center. PATIENT(S): One hundred thirty-seven patients undergoing IVF. INTERVENTION(S): The outcome of 71 patients who had an ovarian cyst of >10 mm detected at ultrasound examination performed on day 3 was compared with that of 66 patients who underwent a similar protocol and did not have an ovarian cyst. MAIN OUTCOME MEASURE(S): Parameters evaluated were the E2 level on the day of hCG administration, the number of follicles, the number of oocytes retrieved, the number of embryos transferred, and the pregnancy rate. RESULT(S): The E2 level on the day of hCG administration and the number of mature oocytes retrieved were lower in the group with a baseline cyst. The pregnancy rate also was significantly lower in the group with a cyst (24% versus 41%). The presence of a baseline ovarian cyst decreases the odds of pregnancy 0.37-fold (95% confidence interval, 0.16-0.87). CONCLUSION(S): A baseline ovarian cyst on cycle day 3 was associated with a poorer outcome after IVF-ET.

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MeSH descriptors

Embryo Transfer Fertilization in Vitro Ovarian Cysts Ovarian Hyperstimulation Syndrome Adult Female Humans Logistic Models Ovarian Cysts Ovarian Hyperstimulation Syndrome Pregnancy Pregnancy Rate Receptors, LHRH Receptors, LHRH Regression Analysis Retrospective Studies

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