Pathologic findings in fallopian tubes of women with chronic pelvic pain after Essure placement

Alexandra Rubin, RUBIN A, Jie-Fu Chen, Jie‐Fu Chen, Veade A, Ashley Veade, Hagemann IS, Ian S. Hagemann
Contraception · 2020 · vol. 102(2) , pp. 133–136 · doi:10.1016/j.contraception.2020.04.010 · PMID:32353358 · W3018787544
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This paper describes the microscopic changes observed in the fallopian tubes of women experiencing chronic pelvic pain following Essure placement.

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Abstract

BACKGROUND: Pelvic pain has been associated with Essure, a permanent contraceptive implant. Here we describe histopathologic findings in long-term Essure users with chronic pelvic pain. METHODS: We descriptively evaluated and compared histopathologic features of hysterectomy specimens removed for a primary diagnosis of chronic pelvic pain from women with (n = 3) and without (n = 3) prior placement of Essure coils (mean of 8.6 years prior). RESULTS: Interstitial fallopian tubes of Essure patients demonstrated fibrosis. Two cases had flattening of ampullary epithelial folds. Tubes of Essure users showed no acute inflammation, but 2/3 showed focal chronic inflammation. All patients had additional findings, such as endometriosis, adenomyosis or leiomyomas, that could be associated with pain. CONCLUSIONS: Given the minimal and bland inflammation in Essure cases, symptoms may more plausibly be ascribed to confounding gynecologic conditions or other mechanisms.

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Condition tags

chronic_pelvic_pain

MeSH descriptors

Chronic Pain Chronic Pain Chronic Pain Sterilization, Tubal Sterilization, Tubal Sterilization, Tubal Fallopian Tubes Fallopian Tubes Fallopian Tubes Female Female Humans Humans Hysteroscopy Hysteroscopy Pelvic Pain Pelvic Pain Pelvic Pain Pregnancy Pregnancy

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europepmc
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openalex
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pubmed
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License: CC0 · commercial use OK