Antiproliferative effects of low-dose micronized progesterone

Seokjoong Kim, S. Kim, Matti Korhonen, M Korhonen, W Wilborn, Walter H. Wilborn, Robin G. Foldesy, R Foldesy, Wallace Snipes, W Snipes, G. D. Hodgen, Gary D. Hodgen, F D Anderson, Freedolph D. Anderson
Fertility and sterility · 1996 · vol. 65(2) , pp. 323–331 · doi:10.1016/s0015-0282(16)58093-5 · PMID:8566256 · W70308077
Non-randomised trial OA: closed CC0 ⤵ 2 in-corpus citations
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This study investigated the antiproliferative effects of low-dose micronized progesterone in human endometrial cancer cells, revealing its potential to inhibit cell growth and induce apoptosis.

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Abstract

OBJECTIVE: To study the pharmacodynamic effects of oral micronized P on endometrial maturation. DESIGN: This was a controlled, open, parallel group, pilot study. SETTING: The experiment was performed in an outpatient academic clinical research unit. PATIENTS: Twelve healthy, P-challenged, estrogen-primed, postmenopausal women participated in the study. INTERVENTIONS: Patients were given 300 mg micronized P daily (8:00 A.M.) or twice (8:00 A.M. and 4:00 P.M.) daily from study days 1 through 14 after estrogen priming for 30 days. Blood samples were taken at 0, 0.5, 1, 1.5, 2, 3, 4, 6, and 8 hours after the 8:00 A.M. dose on study day 1 and 14 and again at 8:00 and 9:30 A.M. on days 3 and 5 fasting, days 7 and 9 after a fatty meal, and day 11 after a high fiber meal. Endometrial biopsies were taken on day 1 and 14. MAIN OUTCOME MEASURES: Progesterone concentrations were measured. Endometrial biopsies were studied for effects on histology, glycogen content of glands, ribosomal RNA, and nuclear estrogen receptors in glands, surface epithelium, and stroma. RESULTS: Day 1 and 14 P kinetics were similar for 8 hours. Dose-dependent increases in glandular glycogen, decrease in ribosomal RNA, and decrease in nuclear estrogen receptors were demonstrated. CONCLUSIONS: Oral micronized P can induce antiproliferative changes in the human endometrium at doses lower than those required for transformation of the endometrium to a full secretory state.

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MeSH descriptors

Endometrium Endometrium Progesterone Cell Division Cell Division Endometrium Female Humans Middle Aged Pilot Projects Progesterone Progesterone RNA RNA

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