Observation of Treatment with Enantone in Moderate or Severe Endometriosis After Conservative Surgery

Objective To evaluate the efficiency and security of enantone in treatment of moderate or severe endometriosis after conservative surgery.Methods 108 women with moderate or severe endometriosis after conservative surgery were randomly divided into three groups: the enantone group with 35 cases,the gestrinone group with 40 cases and the non-drug group with 33 cases.The clinical efficacy,pregnancy,menstruation changes and the incidence of adverse reactions were observed and compared.Results Both the enantone group and the gestrinone group achieved significant relief of pelvic symptoms and signs(88.6% and 67.5%) compared with the non-drug group(42.4%)(P0.05).The complete remission rates and the amenorrhea rates of the symptoms and signs in enantone group were higher than in the gestrinone group(P0.05).The enantone group had shorter time for drug rehabilitation and fewer side effects and better tolerance and compliance compared with the gestrinone group.The serum estradiol(E2) in enantone group and gestrinone group were significantly decreased after treatment compared with that of before treatment and the non-drug group(P0.05).The serum estradiol of enantone group after treatment were significantly decreased compared with that of the gestrinone group(P0.05).The serum follicle stimulating hormone(FSH),luteinizing hormone(LH) levels did not change significantly among three groups(P0.05),and had no significant difference before and after treatment(P0.05).Conclusion Enantone seems to be effective and safe for endometriosis after conservative surgery with few side effects and well tolerance.