Impact of six months of GnRH agonist therapy for endometriosis. Is there an age-related effect on bone mineral density?
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Abstract
OBJECTIVE: To determine if there is an age-related effect on bone mineral density (BMD) loss with GnRH agonist treatment of endometriosis and, in particular, whether the impact of this therapy in terms of BMD loss is different if it is used at an age prior to attainment of peak BMD than after attaining it. STUDY DESIGN: Data from a randomized, double-placebo-controlled clinical trial comparing efficacy and safety of two GnRH agonists, without add-back, for the treatment of endometriosis, were analyzed. RESULTS: No significant age-related effect was detected for either GnRH agonist on absolute BMD loss with a single, six-month course. However, in women at an age prior to peak BMD, prevention of the natural increase in BMD with these drugs may prevent women from attaining their peak BMD and thus increase their risk of osteoporosis in later life. CONCLUSION: GnRH agonists should be used with caution and perhaps only with strategies designed to minimize the impact on BMD in women prior to attainment of peak BMD.
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Cited by (8)
- The effect of pharmacological cessation and restoration of menstrual cycle on bone metabolism in premenopausal women with endometriosis 2022
- Molecular alterations in eutopic endometrium of women with endometriosis and implications in its diagnostic 2018
- Endometriotic inflammatory microenvironment induced by macrophages can be targeted by niclosamide† 2018
- Niclosamide As a Potential Nonsteroidal Therapy for Endometriosis That Preserves Reproductive Function in an Experimental Mouse Model 2016
- [Relationship among anthropometric and gluco-metabolic parameters, bone mineral density and endometriosis]. 2014
- Hormone therapy for endometriosis and surgical menopause 2009
- Targeting Mast Cells in Endometriosis with Janus Kinase 3 Inhibitor, JANEX‐1 2007
- GnRH analogs: Options for endometriosis-associated pain treatment 2006
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