An analysis of endometrial bleeding patterns in perimenopausal women

In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2017 · vol. 6(7) , pp. 2776 · doi:10.18203/2320-1770.ijrcog20172534 · W2620308591
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This cross-sectional study of 100 perimenopausal women with abnormal uterine bleeding found that heavy menstrual bleeding was most common in the 40-44 age group and showed good correlation between clinical diagnoses, including adenomyosis, and histopathological findings.

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This cross-sectional study evaluated 100 perimenopausal women aged 40 to 59 years presenting with abnormal uterine bleeding at a tertiary care center. Researchers utilized diagnostic techniques including dilatation and curettage, suction aspiration, and hysteroscopy to correlate clinical diagnoses with endometrial histopathology. The findings revealed that heavy menstrual bleeding was the most common symptom, with structural causes like fibroids and adenomyosis accounting for significant portions of cases alongside non-structural ovulatory dysfunction. The paper explicitly lists adenomyosis as one of the clinical diagnoses identified in 9% of the cohort, linking it directly to the corpus scope through its classification under AUB (Adenomyosis).

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Abstract

Background: Perimenopause is the period surrounding menopause characterized by ovulatory dysfunction and menstrual irregularities. Taking into consideration the importance of perimenopause and its consequences, we decided to study this topic in order to know the different menstrual irregularities in relation to age, the spectrum of endometrial histopathology, in relation to various gynaecological conditions as per the PALMCOEIN classification of AUB.Methods: The study population comprised of 100 women in the age group of 40- 59 years who reported to our tertiary care centre of Armed Forces for evaluation of abnormal uterine bleeding. The study was a community based cross - sectional descriptive study. Patients were examined, using one of the three techniques – Dilatation and curettage, suction aspiration and hysteroscopy and endometrial biopsy.Results: Out of the 100 women evaluated for perimenopausal bleeding, heavy menstrual bleeding was the commonest in 53% cases. The maximum no. of cases was in 40-44-year age group (57.44 %). The clinical diagnosis of fibroid uterus was found in 45% cases, AUB (O) in 36% cases, AUB (Polyp) in 8% cases, AUB (Adenomyosis) in 9% cases and AUB (Malignancy) in 2% cases. On endometrial curettage, proliferative type of endometrium was found in 43% cases, secretory type in 18% cases and hyperplasia was found in 37% cases. Out of 2 cases of atypical hyperplasia 1 case each (50%) was found in the age group of 50-54 years and 55-59 years, respectively.Conclusions: In the present study, there was good correlation between abnormal uterine bleeding, clinical diagnosis and histopathological findings.
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Background

Perimenopause is the period surrounding menopause characterized by ovulatory dysfunction and menstrual irregularities. Taking into consideration the importance of perimenopause and its consequences, we decided to study this topic in order to know the different menstrual irregularities in relation to age, the spectrum of endometrial histopathology, in relation to various gynaecological conditions as per the PALMCOEIN classification of AUB.

Methods

The study population comprised of 100 women in the age group of 40- 59 years who reported to our tertiary care centre of Armed Forces for evaluation of abnormal uterine bleeding. The study was a community based cross - sectional descriptive study. Patients were examined, using one of the three techniques – Dilatation and curettage, suction aspiration and hysteroscopy and endometrial biopsy.

Results

Out of the 100 women evaluated for perimenopausal bleeding, heavy menstrual bleeding was the commonest in 53% cases. The maximum no. of cases was in 40-44-year age group (57.44 %). The clinical diagnosis of fibroid uterus was found in 45% cases, AUB (O) in 36% cases, AUB (Polyp) in 8% cases, AUB (Adenomyosis) in 9% cases and AUB (Malignancy) in 2% cases. On endometrial curettage, proliferative type of endometrium was found in 43% cases, secretory type in 18% cases and hyperplasia was found in 37% cases. Out of 2 cases of atypical hyperplasia 1 case each (50%) was found in the age group of 50-54 years and 55-59 years, respectively.

Conclusions

In the present study, there was good correlation between abnormal uterine bleeding, clinical diagnosis and histopathological findings. Metrics

References

Speroff Leon. Menopause and Perimenopausal transition. Clinical Endocrinol. 2005;17:628-32. Munro MG, Critchley HOD, Broder S, Fraser IS. For the FIGO Working Group on menstrual disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynecol Obstet. 2011;113:3-13. Singh S, Best C, Dunn S, Leyland N, Wolfman WL, Wolfman W et al. Abnormal Uterine Bleeding in Pre-Menopausal Women. J Obstet Gynaecol Canada. 2013;35(5):S1-S28. Muzaffar M, Akhtar K, Yamin S, Rehman M, Iqbal W. Menstrual irregularities with excessive blood loss: a clinico-pathological correlation. JPMA. 2005;55(11):486-9. Pyari JS, Rekha S, Srivastava PK, Madhumati G, Pandey M. A comparative diagnostic evaluation of hysteroscopy, transvaginal ultrasonography and histopathological examination in cases of abnormal uterine bleeding. J Obstet Gynecol India. 2006;56(3):240-3. Babbar K, Jogi S, Arya RC. Clinical pattern and spectrum of endometrial pathologies in perimenopausal and post-menopausal women: Experience in a tertiary care institute. JSAFOMS. 2015;3(1):9-14. Wise LA, Palmer JR, Stewart JA, Rosenberg L. Age-specific incidence rates for self-reported uterine leiomyomata in the Black Women’s Health study. Obstet Gynecol. 2005;105(3):563-8. Jutras ML, Cowan BD. Abnormal bleeding in the climacteric. Obstetr Gynecol Clini North America. 1990 Jun;17(2):409-25. Cornitescu FI, Tanase F, Simionescu C, Iliescu D. Clinical, histopathological and therapeutic considerations in non-neoplastic abnormal uterine bleeding in menopause transition. Rom J Morphol Embryol. 2011;52(3):759-65. Aftabbudin M. Diagnostic hysteroscopy-its evaluation. J Obstet Gynecol India. 1992;42(5):699-703. Buttram VC, Reiter VC. Uterine leiomyomata; aetiology, symptomatology, and management. Prog Clin Biol Res. 1986;225:275-6. Pilli GS, Sethi B, Dhaded AV, Mathur PR. Dysfunctional Uterine Bleeding (Study of 100 cases). J Obstet Gynecol India. 2002;52(3):87-9. Sameera MM, Al-Jufairi ZA. Abnormal uterine bleeding. Diagnostic value of hysteroscopy. Saudi Med J. 2001;22(2):153-6. Jyotsna, Kamlesh M, Sharma S. Role of hysteroscopy and laparoscopy in evaluation of abnormal uterine bleeding. JK Sci. 2004;6(1):392-7. Girija MK. Transvaginal ultrasound for endometrial thickness in abnormal uterine bleeding with its histopathology. J Med Dent Sci Res. 2016;3(4):4-7. Malik S, Sharma JB, Gulati N, Jain K. A clinico- pathological study of adenomyosis. J Obstet Gynecol India. 1992;42:234-38. Majumdar M, Sudarshan S. Diagnosis of Adenomyosis – still a clinical dilemma. J Obstet Gynecol India. 1997;7(1):94-99. Bharadwaj Namratra, Saxena K, Maheshwari Veena, Bharadwaj AK, Mehndi Ghazala. Early diagnosis of endometrial carcinoma by uterine aspiration cytology. J Obstet Gynecol India. 2001;51(3):140-2. Bolde SA, Pudale SS, Pandit GA, Matkari PP. Histopathological study of endometrium in cases of abnormal uterine bleeding. Int J Res Med Sci. 2014;2(4):1378-81. Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan J, Panicker VK. Study of endometrial pathology in abnormal uterine bleeding. J Obstet Gynecol India. 2011;61(4):426. Pinto RY. Dysfunctional uterine bleeding in premenopausal women. J Obstet Gynecol India. 1969;19:606-14. Desai K, Patole KP, Kathaley M. Endometrial evaluation by histopathology in abnormal uterine bleeding in perimenopausal and postmenopausal patients. MVP J Med Sci. 2014;1(2):75-79. Patil, Dave. Hysteroscopy in excessive uterine bleeding. J Obstet Gynecol India. 1993;43(6):605-10. Zlatkov V, Radeva V, Cholakova G, Mikhova A, Bŭrzakov G, Velinov E et al. Assessment of irregular uterine bleeding in premenopausal women. Akush Ginekol (Sofiia). 2002;41(5):33-35. Muzaffar M, Akhtar K, Yamin S, Rehman M, Iqbal W. Menstrual irregularities with excessive blood loss: a clinico-pathological correlation. JPMA. 2005; 55(11):486-9. Forae GD, Aligbe JU. Histopathological patterns of endometrial lesions in patients with abnormal uterine bleeding in a cosmopolitan population. J Basic Clini Reprod Sci. 2013;2(2):101-4. Singh P, Jaiswal VK, Garg P. Endometrial patterns in abnormal uterine bleeding. Int J Biomed Res. 2016;7(5):244-50. Emons G, Beckmann MW, Schmidt D, Mallmann P. New WHO Classification of Endometrial Hyperplasias. Geburtshilfe und Frauenheilkunde. 2015;75(2):135-6. Chandoul A, Mahbouli S, Messaoudi Y, Zauene H, Basly M, Messaoudi F et al. Role of uterine curettage in endometrial pathology. Report of 200 cases. Tunis Med. 2002;80(8):445-9.

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