Biochemical markers as a predictor for lymph-node involvement in patients with cervical-cancer of the uterus.

Kobayashi H, Fujishiro S, Terao T
International journal of oncology · 1994 · doi:10.3892/ijo.4.5.1053 · PMID:21567019
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This study assessed tumor-associated urokinase-type plasminogen activator and granulocyte-derived elastase as predictors for lymph node involvement in stage II cervical cancer, finding strong uPA staining correlated with a significantly higher rate of lymph node positivity.

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This study evaluated tumor-associated urokinase-type plasminogen activator (uPA) and granulocyte-derived elastase as predictors for lymph node involvement in patients with stage II cervical cancer. Researchers quantified these markers in tissue samples from 29 individuals, finding that strong uPA staining correlated significantly with a higher rate of positive lymph nodes compared to weak staining. The investigation also noted intense inflammatory reactions at the interface between malignant cells and normal stroma, where phagocytic cells secreted elastase. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

The present study was undertaken to assess the role of tumor associated urokinase-type plasminogen activator (uPA) and tumor infiltrating granulocyte-derived elastase as a positive and a negative predictor for lymph node involvement in patients with stage II cervical cancer of the uterus. uPA and uPA binding proteins (uPA receptors) were quantitated enzymologically and/or immunologically in cell membrane preparations obtained from cancer tissues. The cell membrane preparations express pro-uPA/uPA, uPA is bound to a specific type of surface receptors, of which more than 50% are saturated. Most of the receptor-bound uPA is enzymologically inactive pro-uPA. We have investigated the localization of pro-uPA/uPA and granulocyte elastase immunohistochemically and semiquantitated in formalin-fixed paraffin-embedded tissue sections in 13 patients with pelvic lymph node involvement and in 16 cases without lymph node involvement. Strong uPA staining was found in areas with invasive growth and degradation of surrounding normal tissue. A significant higher lymph node positive rate was observed in patients who had tumors with strong uPA staining than in those with weak staining (p<0.05). In contrast, phagocytic cells were found close to the tumor cells, and were located in aggregates or diffusely spread within tumor stroma surrounding the tumor nests. The inflammatory reaction seems to be most intense at the border between surrounding normal stromal cells and malignant epithelial cells. These cells produced and secreted granulocyte elastase.
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Print ISSN: 1019-6439 Online ISSN: 1791-2423 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 1053-1059|Published online on: May 1, 1994https://doi.org/10.3892/ijo.4.5.1053 - Expand metrics + The present study was undertaken to assess the role of tumor associated urokinase-type plasminogen activator (uPA) and tumor infiltrating granulocyte-derived elastase as a positive and a negative predictor for lymph node involvement in patients with stage II cervical cancer of the uterus. uPA and uPA binding proteins (uPA receptors) were quantitated enzymologically and/or immunologically in cell membrane preparations obtained from cancer tissues. The cell membrane preparations express pro-uPA/uPA, uPA is bound to a specific type of surface receptors, of which more than 50% are saturated. Most of the receptor-bound uPA is enzymologically inactive pro-uPA. We have investigated the localization of pro-uPA/uPA and granulocyte elastase immunohistochemically and semiquantitated in formalin-fixed paraffin-embedded tissue sections in 13 patients with pelvic lymph node involvement and in 16 cases without lymph node involvement. Strong uPA staining was found in areas with invasive growth and degradation of surrounding normal tissue. A significant higher lymph node positive rate was observed in patients who had tumors with strong uPA staining than in those with weak staining (p<0.05). In contrast, phagocytic cells were found close to the tumor cells, and were located in aggregates or diffusely spread within tumor stroma surrounding the tumor nests. The inflammatory reaction seems to be most intense at the border between surrounding normal stromal cells and malignant epithelial cells. These cells produced and secreted granulocyte elastase. Copy and paste a formatted citation Spandidos Publications style KOBAYASHI H, FUJISHIRO S and TERAO T: BIOCHEMICAL MARKERS AS A PREDICTOR FOR LYMPH-NODE INVOLVEMENT IN PATIENTS WITH CERVICAL-CANCER OF THE UTERUS. Int J Oncol 4: 1053-1059, 1994. APA KOBAYASHI, H., FUJISHIRO, S., & TERAO, T. (1994). BIOCHEMICAL MARKERS AS A PREDICTOR FOR LYMPH-NODE INVOLVEMENT IN PATIENTS WITH CERVICAL-CANCER OF THE UTERUS. International Journal of Oncology, 4, 1053-1059. https://doi.org/10.3892/ijo.4.5.1053 MLA KOBAYASHI, H., FUJISHIRO, S., TERAO, T."BIOCHEMICAL MARKERS AS A PREDICTOR FOR LYMPH-NODE INVOLVEMENT IN PATIENTS WITH CERVICAL-CANCER OF THE UTERUS". International Journal of Oncology 4.5 (1994): 1053-1059. Chicago KOBAYASHI, H., FUJISHIRO, S., TERAO, T."BIOCHEMICAL MARKERS AS A PREDICTOR FOR LYMPH-NODE INVOLVEMENT IN PATIENTS WITH CERVICAL-CANCER OF THE UTERUS". International Journal of Oncology 4, no. 5 (1994): 1053-1059. https://doi.org/10.3892/ijo.4.5.1053

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