Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

P F Donderwinkel; Peter F.J. Donderwinkel; Hester van der Vaart; H van der Vaart; V M Wolters; Victorien M. Wolters; Arnold Simons; A H Simons; Gerard Kroon; G Kroon; M. J. Heineman

doi:10.1016/s0015-0282(99)00518-x

Treatment of patients with long-standing unexplained subfertility with in vitro fertilization

P F Donderwinkel, Peter F.J. Donderwinkel, Hester van der Vaart, H van der Vaart, V M Wolters, Victorien M. Wolters, Arnold Simons, A H Simons, Gerard Kroon, G Kroon, M. J. Heineman

Fertility and sterility · 2000 · vol. 73(2) , pp. 334–337 · doi:10.1016/s0015-0282(99)00518-x · PMID:10685539 · W2122452346

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This paper investigates the effectiveness of in vitro fertilization (IVF) for treating long-standing unexplained subfertility.

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Abstract

OBJECTIVE: To evaluate whether IVF is an effective treatment for long-standing unexplained subfertility. DESIGN: Retrospective cohort study. SETTING: Tertiary care infertility center in a university hospital. PATIENT(S): Two hundred two couples with unexplained subfertility of 2 years' duration or more who attended the center for their first IVF attempt. INTERVENTION(S): Couples were placed on a waiting list for IVF. They received no treatment until IVF was started. MAIN OUTCOME MEASURE(S): Pregnancy rate (PR) while on the waiting list and PR after IVF treatment. RESULT(S): Complete data sets were available for 131 couples. Seventeen of 131 women became pregnant while waiting for IVF treatment (PR 0.9% per exposure cycle), whereas 45 of 119 receiving IVF treatment became pregnant (PR 17% per IVF attempt). CONCLUSION(S): IVF treatment has substantial added value over waiting and is an efficient treatment for long-standing unexplained subfertility.

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MeSH descriptors

Fertilization in Vitro Infertility, Female Adult Female Humans Infertility, Female Life Tables Pregnancy Pregnancy Rate Retrospective Studies Time Factors

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Treatment-independent pregnancy among infertile couples 1983

Cited by (1)

Female Infertility: Other Causes 2001

References (10)

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Cited by (1)

Female Infertility: Other Causes 2001

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[1] Treatment-independent pregnancy among infertile couples 1983