Microbial transformation of danazol

M. Iqbal Choudhary, Azizuddin, Atta-ur-Rahman, Atta‐ur Rahman
Natural product letters · 2002 · vol. 16(2) , pp. 101–106 · doi:10.1080/10575630290019994 · PMID:11990425 · W2044953508
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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Fermentation of danazol with *Fusarium lini*, *Aspergillus niger*, and *Cephalosporium aphidicola* yielded two hydroxylated derivatives, while *Bacillus cerus* yielded only one.

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Abstract

Danazol (17beta-hydroxy-17alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium lini, Aspergillus niger, and Cephalosporium aphidicola yielded 17beta-hydroxy-2-(hydroxymethyl)-17-alpha-pregn-4-en-20-yn-3-one (2) and 17beta-hydroxy-2-(hydroxymethyl)-17 alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Bacillus cerus yielded compound 2 only.

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MeSH descriptors

Danazol Danazol Acremonium Acremonium Aspergillus niger Aspergillus niger Bacillus cereus Bacillus cereus Biotransformation Danazol Danazol Fermentation Fusarium Fusarium Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular

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