Role of biomarkers CA-125, CA-15.3 and CA-19.9 in the distinction between endometriomas and ovarian neoplasms

Jéssica de Souza Magalhães, Magalhães JS, Millena Prata Jammal, Jammal MP, Crispim PCA, Paula Carolina Arvelos Crispim, Eddie Fernando Candido Murta, Eddie Fernando Cândido Murta, Rosekeila Simões Nomelini
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2021 · vol. 26(3) , pp. 268–274 · doi:10.1080/1354750x.2021.1885490 · PMID:33554683 · W3127247697
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CA-19.9 and its combination with CA-125 effectively distinguish endometriomas from benign and malignant ovarian neoplasms.

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Abstract

PURPOSE: To evaluate the utilisation of CA-125, CA-15.3 and CA-19.9 in differentiating between ovarian neoplasms and endometriomas, and the best cut-off value for these tumour markers in this differentiation. MATERIALS AND METHODS: Preoperative serum values of CA-125, CA-15.3 and CA-19.9 were evaluated in 265 patients undergoing surgery for adnexal masses, being 32 non-neoplastic lesions, 134 benign neoplasms, 19 borderline tumours, 36 malignant neoplasms, and 44 endometriomas. ROC curves and Univariate and multivariate analyses were performed. RESULTS: Only CA-19.9 was useful in differentiating between endometriomas and ovarian neoplasms (benign and malignant tumours), being this marker found at higher levels in endometriomas. In multivariate analyses, CA-19.9 greater than 22.3 U/mL was considered an independent factor for the diagnosis of endometrioma, comparing endometrioma and ovarian cancer. Comparing endometrioma and all other groups, the clustering analysis using the combination CA-125 > 34.28 U/mL and CA-19.9 > 19.12 U/mL demonstrated that this association was considered an independent factor for the diagnosis of endometrioma. CONCLUSION: CA-9.9 is useful in distinguishing between endometriomas and ovarian cancer, and its combination with CA-125 is useful in differentiating endometrioma from other ovarian lesions.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate CA-125 Antigen Endometriosis Membrane Proteins Mucin-1 Ovarian Neoplasms Adolescent Adolescent Adult Adult Aged Aged Antigens, Tumor-Associated, Carbohydrate Antigens, Tumor-Associated, Carbohydrate CA-125 Antigen CA-125 Antigen Child Child Diagnosis, Differential Diagnosis, Differential

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References (21)

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