Cyclic relapses of thrombotic thrombocytopenic purpura

M. Udvardy, I. BORKA, Kálmán Racz, K Racz, J Harsfalvi, Jolán Hársfalvi, Z Boda, K Rak, Kálmán Rák
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 1994 · vol. 5(2) , pp. 305–308 · doi:10.1097/00001721-199404000-00021 · PMID:8054463 · W1970371100
Case report OA: closed CC0
Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-11 ⓘ

This case report describes a male patient with cyclic thrombotic thrombocytopenic purpura relapses occurring every 26-30 days, which were managed variably by cyclosporin A and cryopreserved plasma therapy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-07 · read from full text ⓘ

This case report describes a 24-year-old male who experienced recurrent thrombotic thrombocytopenic purpura with regular cycles of relapse occurring every 26 to 30 days despite treatment with corticosteroids, aspirin, splenectomy, and danazol. The patient achieved complete remission following the administration of cyclosporin A, although reducing the dosage led to milder but irregular recurrences. Cryopreserved plasma collected during periods of remission was also found to be effective in managing subsequent episodes. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

A 24-year-old male patient was first observed with full-blown acute thrombotic thrombocytopenic purpura in 1991. Complete remission was achieved with plasma and plasmapheresis therapy, but in spite of continuous corticosteroid and aspirin administration, thrombocytopenic (megakaryocytic) relapses were observed every 26-30 days. Splenectomy and danazol failed to prevent the recurrence of the disease. Surprisingly, cyclosporin A (5 mg/kg/day) administration resulted in a complete transitional remission, but after dose reduction a less regular pattern of repeated milder recurrences was observed. Cryopreserved plasma, obtained from the patient during remission also proved to be effective in treating the last two thrombocytopenic episodes.
Full text 991 characters · extracted from oa-doi-fallback · click to expand
Case Report: PDF Only Cyclic relapses of thrombotic thrombocytopenic purpura - M. Udvardy - I. Borka - K. Racz - J. Harsfalvi - Z. Boda - K. Rak Blood Coagulation & Fibrinolysis 5(2):p 305-308, April 1994. A 24-year-old male patient was first observed with full-blown acute thrombotic thrombocytopenic purpura in 1991. Complete remission was achieved with plasma and plasmapheresis therapy, but in spite of continuous corticosteroid and aspirin administration, thrombocytopenic (megakaryocytic) relapses were observed every 26–30 days. Splenectomy and danazol failed to prevent the recurrence of the disease. Surprisingly, cyclosporin A (5 mg/kg/day) administration resulted in a complete transitional remission, but after dose reduction a less regular pattern of repeated milder recurrences was observed. Cryopreserved plasma, obtained from the patient during remission also proved to be effective in treating the last two thrombocytopenic episodes. Copyright © Lippincott-Raven Publishers.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

MeSH descriptors

Periodicity Purpura, Thrombotic Thrombocytopenic Adult Combined Modality Therapy Humans Male Purpura, Thrombotic Thrombocytopenic Recurrence

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-11T06:10:27.824888+00:00
pubmed
last seen: 2026-10-08T21:59:20.378211+00:00
unpaywall
last seen: 2026-10-23T06:24:35.503409+00:00
License: CC0 · commercial use OK