Effects of Yiweining Recipe on expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in ectopic endometrium of rats with endometriosis

Fan Qu, Zhou J, Jue Zhou, Yang DX, Dong-Xia Yang, Ma WG, Wen-guang Ma, Ma BZ, Bao-zhang Ma
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2006 · vol. 4(6) , pp. 634–638 · doi:10.3736/jcim20060619 · PMID:17090383 · W2055680308
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Yiweining Recipe reduced the expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in the ectopic endometrium of rats with induced endometriosis.

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Abstract

OBJECTIVE: To explore the effects of Yiweining Recipe (YWNR), a compound Chinese herbal medicine, on expressions of metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) mRNAs in rats with endometriosis (EM). METHODS: Operational self-transplantation was applied in establishing the rat models. Detection of MMP-2 and COX-2 mRNAs was conducted with hybridization in situ. RESULTS: There were significant differences in the expressions of MMP-2 and COX-2 mRNAs between the untreated group and the high-dose YWNR-treated group. YWNR could reduce the expressions of MMP-2 and COX-2 mRNAs. CONCLUSION: YWNR can treat EM through reducing the positive expressions of MMP-2 and COX-2 mRNAs.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Drugs, Chinese Herbal Endometriosis Matrix Metalloproteinase 2 Phytotherapy Phytotherapy Uterine Diseases Animals Animals Cyclooxygenase 2 Cyclooxygenase 2 Drugs, Chinese Herbal Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis Endometriosis Endometriosis Female Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

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