Is AMH Prediction of Menopause?

In: Medical alphabet · 2023 · pp. 37–41 · doi:10.33667/2078-5631-2023-3-37-41 · W4362555466
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This chapter summarizes current knowledge on using anti-Müllerian hormone (AMH) to predict menopause, discussing its role in normal and premature menopause and related fertility disorders.

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Abstract

Anti-Müllerian Hormone (AMH) is produced by small antral follicles and has evolved over the past three decades as an assumed potential marker of the number of follicles in the human ovaries, also known as ovarian reserve. This quantitative measure, given the gradual decline over time and its non-replenishable feature, could be the dreamed marker for predicting the fnal exhaustion of ovarian storage: the post-menopause. This introductory chapter summarizes current knowledge with regard to the contribution of serum AMH measurements to predict age of normal menopause and critically discuss its potential in this regard. Furthermore, its predictive role in the context of menopause in association with several frequently occurring fertility disorders such as premature menopause, polycystic ovarian syndrome and endometriosis are discussed. Overall, while ovarian reserve markers including AMH are unmistakably related to age at menopause, they are insuffciently precise to inform on an individual’s journey of ovarian aging.
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Антимюллеровский гормон предиктор менопаузы? https://doi.org/10.33667/2078-5631-2023-3-37-41 Аннотация В течение последних трех десятилетий считается, что в качестве потенциального маркера количества фолликулов в яичниках человека, известного как овариальный резерв, является антимюллеровский гормон (АМГ), который вырабатывается антральными фолликулами. Эта количественная мера, учитывая ее постепенное снижение с течением времени и ее невосполнимость, может быть предполагаемым маркером для предсказания окончательного истощения запасов яичников: постменопаузы. Во введении обобщаются современные знания о значении уровня АМГ в сыворотке в прогнозирование возраста нормальной менопаузы. Кроме того, обсуждается его прогностическая роль в контексте менопаузы в связи с несколькими часто встречающимися причинами нарушения фертильности, такими как преждевременная менопауза, синдром поликистозных яичников и эндометриоз. 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DOI: 10.1093/humrep/dew278 31. van Dorp W., van den Heuvel-Eibrink M.M., de Vries A. C., Pluijm S. M., Visser J. A., Pieters R. Decreased Serum Anti-Müllerian Hormone Levels in Girls With Newly Diagnosed Cancer. Hum. Reprod. (2014). 29:337–42. DOI: 10.1093/humrep/det442 32. Ruth K.S., Day F.R., Hussain J., Martínez-Marchal A., Aiken C.E., Azad A. Genetic Insights Into Biological Mechanisms Governing Human Ovarian Ageing. Nature (2021). 596(7872):393–7. DOI: 10.1038/s41586–021–03779–7 33. Laven J. S.E. Genetics of Menopause and Primary Ovarian Insuffciency: Time for a Paradigm Shift? Semin. Reprod. Med. (2020). 38:256–62. DOI: 10.1055/s-0040–1721796 34. Grootenhuis A., van den Hoogen A., Broekmans F., Torrance H., van Os-Medendorp H., Ockhuijsen H. Young Women’s Opinions on the Use of a Blood Test to Predict the Possibility of Premature Ovarian Failure: A Qualitative Study. Hum. Fertil. (Camb) (2019). 1–11. DOI: 10.1080/14647273.2019.1665198 35. Habbema J. D., Eijkemans M. J., Leridon H., te Velde E. R. Realizing a Desired Family Size: When Should Couples Start? Hum. Reprod. (2015). 30:2215–21. DOI:10.1093/humrep/dev148 36. de Kat A.C., Broekmans F.J.M., Lambalk C.B. Role of AMH in Prediction of Menopause Front Endocrinol (Lausanne). Published online 2021 Sep 14. DOI: 10.3389/fendo.2021.733731 Рецензия Для цитирования: Зайдиева Я.З. Антимюллеровский гормон предиктор менопаузы? Медицинский алфавит. 2023;(3):37-41. https://doi.org/10.33667/2078-5631-2023-3-37-41 For citation: Zaydieva Ya.Z. Is AMH Prediction of Menopause? Medical alphabet. 2023;(3):37-41. (In Russ.) https://doi.org/10.33667/2078-5631-2023-3-37-41 JATS XML

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