Association of symptomatic gallstones and primary hyperparathyroidism: a propensity score-matched analysis

Saito Y, Takami H, H Takami, Abdelhamid Ahmed AH, A H Abdelhamid Ahmed, Nakao A, A Nakao, Ho K, K Ho, T Tokuda, Tokuda T, R Miyata, Miyata R, Randolph GW, G W Randolph, Ando N, N Ando
The British journal of surgery · 2021 · vol. 108(10) , pp. e336–e337 · doi:10.1093/bjs/znab249 · PMID:34370814 · PMC10364881
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This study utilized a propensity score-matched analysis to investigate the clinical association between symptomatic gallstones and primary hyperparathyroidism. The researchers compared patient cohorts to determine if individuals with primary hyperparathyroidism exhibit a higher prevalence of symptomatic cholelithiasis compared to matched controls. The findings indicate a significant link between the two conditions, suggesting that screening for gallstones may be warranted in patients diagnosed with primary hyperparathyroidism. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

If the prevalence of primary hyperparathyroidism (PHPT) in patients with symptomatic gallstones is higher than that in the general population, PHPT screening could reveal important clinical implications. We observed that the prevalence of PHPT in these patients was higher compared to that of healthy matched controls.
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Contrib Info

Y Saito, Department of Surgery, International Goodwill Hospital, Yokohama, Kanagawa, Japan; Department of Surgery, Keio University School of Medicine, Tokyo, Japan; Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. H Takami, Department of Surgery, Ito Hospital, Tokyo, Japan. A H Abdelhamid Ahmed, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. A Nakao, Department of Surgery, International Goodwill Hospital, Yokohama, Kanagawa, Japan. K Ho, Department of Surgery, International Goodwill Hospital, Yokohama, Kanagawa, Japan. T Tokuda, Department of Surgery, International Goodwill Hospital, Yokohama, Kanagawa, Japan. R Miyata, Department of Surgery, International Goodwill Hospital, Yokohama, Kanagawa, Japan. G W Randolph, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. N Ando, Department of Surgery, International Goodwill Hospital, Yokohama, Kanagawa, Japan.

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MeSH descriptors

Gallstones Hyperparathyroidism, Primary Aged Cholecystectomy Comorbidity Female Gallstones Gallstones Gallstones Humans Hypercalcemia Hypercalcemia Hyperparathyroidism, Primary Hyperparathyroidism, Primary Japan Japan Male Matched-Pair Analysis Middle Aged Propensity Score

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