Absorption of 17 beta-estradiol in a neovagina constructed from the peritoneum

W N Willemsen, Wim N.P. Willemsen, J L Mastboom, Jaap L. Mastboom, Chris M.G. Thomas, C M Thomas, R. Rolland
European Journal of Obstetrics & Gynecology and Reproductive Biology · 1985 · vol. 19(4) , pp. 247–253 · doi:10.1016/0028-2243(85)90036-x · PMID:3924675 · W2062240576
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Researchers found that administering micronized 17β-estradiol to patients with peritoneum-constructed neovaginas resulted in significant estradiol absorption and FSH changes, indicating resorption patterns similar to those in women with normal vaginas.

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Abstract

Estrogen absorption from the neovagina was studied by administering 2.0 mg of micronized 17 beta-estradiol (E2) neovaginally to 6 patients. The neovagina in each patient was constructed by using the peritoneum from the pouch of Douglas. A mean peak of circulating E2 concentrations more than 15-times the basal level was achieved 90 min after the application. Until 12.5 h after the application, the E2 levels were significantly (P less than 10(-6)) elevated. FSH levels were significantly (P = 0.003) changed in comparison to the basal serum concentration. There was no significant (P = 0.08) change in LH levels. The resorption of estradiol from the neovagina is similar to that seen in women with normal vaginas.

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MeSH descriptors

Estradiol Peritoneum Vagina Administration, Topical Adolescent Adult Estradiol Estradiol Female Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Luteinizing Hormone Luteinizing Hormone Peritoneum Surgery, Plastic Syndrome Time Factors Uterus Uterus

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