First documented case of endometrial carcinoma in a patient treated with tamoxifen for encapsulating peritoneal sclerosis
This case report documents the first instance of endometrial carcinoma developing in a patient treated with tamoxifen for encapsulating peritoneal sclerosis, highlighting this serious side effect.
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This case report documents the first instance of endometrial carcinoma developing in a 52-year-old woman undergoing treatment for encapsulating peritoneal sclerosis with tamoxifen. The patient, who had received long-term peritoneal dialysis, developed vaginal bleeding after 24 months of therapy, leading to a diagnosis of endometrial cancer that was managed with local irradiation rather than surgery due to her comorbidities. The authors highlight this outcome as evidence that endometrial carcinoma is a rare but serious adverse effect of tamoxifen use in female patients treated for encapsulating peritoneal sclerosis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.
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