First documented case of endometrial carcinoma in a patient treated with tamoxifen for encapsulating peritoneal sclerosis

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This case report documents the first instance of endometrial carcinoma developing in a patient treated with tamoxifen for encapsulating peritoneal sclerosis, highlighting this serious side effect.

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This case report documents the first instance of endometrial carcinoma developing in a 52-year-old woman undergoing treatment for encapsulating peritoneal sclerosis with tamoxifen. The patient, who had received long-term peritoneal dialysis, developed vaginal bleeding after 24 months of therapy, leading to a diagnosis of endometrial cancer that was managed with local irradiation rather than surgery due to her comorbidities. The authors highlight this outcome as evidence that endometrial carcinoma is a rare but serious adverse effect of tamoxifen use in female patients treated for encapsulating peritoneal sclerosis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Conclusions

We would like to emphasize endometrial carcinoma as a rare but serious side effect of tamoxifen treatment that should be taken into consideration when tamoxifen is used to treat EPS in female patients. DISCLOSURES The authors have no financial conflicts of interest to declare.

References

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MeSH descriptors

Anti-Inflammatory Agents Endometrial Neoplasms Peritoneal Fibrosis Tamoxifen Anti-Inflammatory Agents Endometrial Neoplasms Female Humans Intestinal Obstruction Intestinal Obstruction Middle Aged Peritoneal Fibrosis Peritoneal Fibrosis Tamoxifen

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