The concentration of human follicular fluid stromal cell-derived factor-1 is correlated with luteinization in follicles

Akemi Nishigaki, Hidetaka Okada, Rika Okamoto, Kayo Shimoi, Hiroe Miyashiro, Katsuhiko Yasuda, Hideharu Kanzaki
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2012 · vol. 29(3) , pp. 230–234 · doi:10.3109/09513590.2012.736551 · PMID:23193972 · W1993201844
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Human follicular fluid SDF-1 and VEGF concentrations positively correlate with progesterone, and SDF-1 mRNA and protein are expressed in granulosa cells, suggesting roles in luteinization.

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Abstract

Stromal cell-derived factor-1 (SDF-1/CXCL12) and vascular endothelial growth factor (VEGF) are angiogenic factors that have possible roles in ovarian function. The objectives of this study were to investigate the association between the individual concentrations of SDF-1 and VEGF and sex steroid hormones in human preovulatory follicles and to verify the SDF-1 expression in ovarian follicles. Follicular fluid (FF) and luteinizing granulosa cells (LGCs) were collected from follicles at the time of oocyte retrieval. The concentrations of SDF-1, VEGF, estradiol (E₂) and progesterone (P₄) were determined by biochemical assay. The expression levels of SDF-1 mRNA and protein were analyzed by RT-PCR and immunohistochemical analysis, respectively. A total of 177 follicles were analyzed. The FF concentrations of SDF-1 and VEGF positively correlated with P₄ concentrations (r = 0.457 and p < 0.01, r = 0.698 and p < 0.01, respectively), but did not correlate with E₂ concentrations in FF. Furthermore, we confirmed that SDF-1 mRNA was expressed in LGCs and SDF-1 protein is present in the granulosa cells of the human ovary. Our findings suggest that SDF-1, as well as VEGF, may play important modulatory roles in early luteinization of human preovulatory follicles.

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MeSH descriptors

Chemokine CXCL12 Follicular Fluid Luteinization Ovarian Follicle Adult Biomarkers Biomarkers Chemokine CXCL12 Chemokine CXCL12 Estradiol Estradiol Female Follicular Fluid Follicular Fluid Gene Expression Regulation Granulosa Cells Granulosa Cells Humans Immunohistochemistry Linear Models

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