Silibinin-induced endoplasmic reticulum stress and mitochondrial dysfunction suppress growth of endometriotic lesions

Jiyeon Ham, Ham J, Jonggun Kim, Kim J, Bazer FW, Fuller W. Bazer, Whasun Lim, Gwonhwa Song
Journal of cellular physiology · 2018 · vol. 234(4) , pp. 4327–4341 · doi:10.1002/jcp.27212 · PMID:30144397 · W2888590523
Lab / animal OA: closed CC0 ⤵ 13 in-corpus citations
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Silibinin reduced endometriotic lesion growth in mice and human cells by inducing endoplasmic reticulum stress, mitochondrial dysfunction, and apoptosis via oxidative stress and increased calcium levels.

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Abstract

Silibinin is a flavonolignan extracted from milk thistle, which has been used for treating liver disorders, various cancers, and gynecological diseases. However, attempts for treating endometriosis with silibinin are lacking. In this study, we observed that silibinin exerts antiproliferative and apoptotic effects on human endometriotic cell lines VK2/E6E7 and End1/E6E7. We also identified that silibinin-induced oxidative stress and lipid peroxidation in human endometriotic cells. Moreover, we observed upregulation of calcium concentration in the cytosol and mitochondrial matrix, which resulted in mitochondrial dysfunction. Furthermore, induction of endoplasmic reticulum stress signals with rapid mitogen-activated protein kinase (MAPK) pathway signaling resulted in apoptosis of both cells. Using an animal model mimicking the retrograde menstruation hypothesis, we verified the effects of silibinin on reducing endometriotic lesions by inhibiting the expression of inflammatory cytokines in mice. Silibinin might be used as a novel therapeutic agent or supplement for inhibiting progression of endometriosis in vitro and in vivo.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Antioxidants Cell Proliferation Endometriosis Endometrium Endoplasmic Reticulum Stress Mitochondria Silybin Animals Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Antioxidants Antioxidants Apoptosis Apoptosis Apoptosis Calcium Calcium Cell Cycle

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