Management of endometrial modifications in perimenopausal women

Renata Nicula, Nicolae Costin
In: Medicine and Pharmacy Reports · 2015 · vol. 88(2) , pp. 101–110 · doi:10.15386/cjmed-421 · PMID:26528056 · W2039275362
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper outlines the management of endometrial modifications in perimenopausal women, emphasizing standardized classification and tailored treatments for abnormal uterine bleeding based on individual risk factors.

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This paper reviews how endometrial histopathology in perimenopausal women can range from nonproliferative or proliferative benign lesions to malignant lesions, often presenting clinically as abnormal uterine bleeding (AUB). It emphasizes that AUB management should use a standardized classification system and that treatment decisions should be tailored to factors including age, risk factors, symptoms, and cycle irregularities, with both medical and surgical options discussed at a high level. The authors also mention that alternative therapies and diet may improve long-term outcomes, while acknowledging the inherent variability in perimenopause and its hormone levels as a major caveat. This paper is centrally about endometriosis—relevant endometrial modifications and abnormal uterine bleeding during menopausal transition are discussed, but endometriosis is not explicitly addressed.

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Abstract

Perimenopause has a variable length and time of onset and is characterized by its variability in hormonal levels. The histological changes in the perimenopausal endometrium may be represented by nonproliferative or proliferative benign or malignant lesions. A commonly encountered manifestation of endometrium lesions during menopausal transition is the abnormal uterine bleeding (AUB). The clinical management of AUB must follow a standardized classification system for optimal results. The medical and surgical treatment must be adapted according to age, risk factors, symptoms, and cycle irregularities. Use of alternative therapies and proper diet may result in improved long-term outcomes.
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Management of endometrial modifications in perimenopausal women DOI: https://doi.org/10.15386/cjmed-421Keywords: perimenopause, endometrium histopathology, clinical managementAbstract Perimenopause has a variable length and time of onset and is characterized by its variability in hormonal levels. The histological changes in the perimenopausal endometrium may be represented by nonproliferative or proliferative benign or malignant lesions. A commonly encountered manifestation of endometrium lesions during menopausal transition is the abnormal uterine bleeding (AUB). The clinical management of AUB must follow a standardized classification system for optimal results. The medical and surgical treatment must be adapted according to age, risk factors, symptoms, and cycle irregularities. Use of alternative therapies and proper diet may result in improved long-term outcomes. Downloads Published How to Cite Issue Section License The authors are required to transfer the copyright of the published paper to the journal. This is done by agreeing to sign the Copyright Assignment Form. Whenever the case, authors are also required to send permissions to reproduce material (such as illustrations) from the copyright holder. The papers published in the journal are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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