Controlled ovarian hyperstimulation in assisted reproduction: effect on the immune system

A Giuliani, Albrecht Giuliani, W Schoell, J Auner, Johann Auner, W. Urdl
Fertility and sterility · 1998 · vol. 70(5) , pp. 831–835 · doi:10.1016/s0015-0282(98)00282-9 · PMID:9806562 · W1970319923
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This prospective study compared immune cell profiles in women undergoing natural cycles versus controlled ovarian hyperstimulation with GnRH antagonists, finding no significant impact of the latter on the immune system.

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Abstract

OBJECTIVE: To determine how controlled ovarian hyperstimulation (COH) in assisted reproduction affects the immune system. DESIGN: A prospective, nonrandomized, case-control study. SETTING: Academic research setting. PATIENT(S): Women with regular menstrual cycles undergoing COH in an assisted reproduction program. INTERVENTION(S): Blood samples were collected in the early and late follicular phase, at the time of ovulation, and in the luteal phase during a natural cycle, and at four times during the next cycle, which included COH and IVF. MAIN OUTCOME MEASURE(S): Lymphocyte subpopulations and the differential blood count. RESULT(S): In the natural cycles, a significant increase in the total numbers of lymphocytes, B cells, natural killer cells, and CD3+HLADR+ cells was observed in the late follicular phase, whereas the T helper/T suppressor cell ratio declined. In the hyperstimulated cycles, increases were seen in the total numbers of leukocytes and neutrophils on the day of hCG administration; the number of lymphocytes, monocytes, and neutrophils was increased on the day of oocyte retrieval, and the total number of leukocytes and neutrophils increased during the luteal phase. CONCLUSION(S): Controlled ovarian hyperstimulation with hMG and simultaneous administration of a GnRH antagonist did not affect the immune system.

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MeSH descriptors

Embryo Transfer Fertilization in Vitro Immune System Ovarian Hyperstimulation Syndrome Case-Control Studies Female Follicular Phase Follicular Phase Humans Luteal Phase Luteal Phase Ovarian Hyperstimulation Syndrome Ovulation Ovulation

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