Effect of DMPA on IL-1 Alpha in Serum of Women with Endometrioma

Worawun Lupthaluk, Sawaek Weerakiet, Supatra Leelaphiwat, Sasivimol Rattanasiri, Matchuporn Sukprasert
In: Thai Journal of Obstetrics and Gynaecology, Vol 21, Iss 2, Pp 72-79 (2013) · 2013 · W2170915338
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found no significant difference in serum IL-1α levels between women with endometrioma treated with DMPA post-surgery versus surgery alone, though DMPA did reduce pain scores at 12 weeks.

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This randomized clinical trial studied 35 women with endometrioma undergoing conservative surgery, assigning participants to surgery plus postoperative DMPA 150 mg intramuscular or surgery alone. Serum IL-1α levels were measured by ELISA, and pain was assessed using visual analog scale scores at 2 and 12 weeks after the operation. IL-1α serum levels did not differ significantly between groups at either time point, nor did pre- versus postoperative IL-1α change within groups. Pain scores decreased significantly in both groups after surgery, with significantly less pain at 12 weeks in the DMPA group. This paper is centrally about endometriosis—specifically endometrioma and the effect of DMPA on IL-1α and postoperative pain.

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Abstract

Objective: To study the effect of DMPA on serum IL-1α in women with endometrioma undergoing the conservative surgery.Materials and methods:A randomized clinical trial was performed in thirty-five women with endometrioma who underwent conservative surgery in Reproductive Endocrinology and Laparoscopy clinic in Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital. These patients were randomly assigned to one of the following treatments: group A surgery and postoperative treatment with DMPA 150 mg intramuscular or group B surgery alone. Serum IL-1α level was measured by enzyme-linked immunosorbent assay (ELISA) in both groups. Pain scores were evaluated using a visual analog scale (VAS) at 2 and 12 weeks after the operation.Results: There was no significant difference in IL-1α serum levels between both groups at 2 weeks and 12 weeks after the surgery (p = 0.06 and 0.86 respectively). There was no significant difference in pre and postoperative IL-1α level between both group (p = 0.23 and 1.00 respectively). Pain scores of both groups were significantly decreased at 2 weeks and 12 weeks after the surgery (p < 0.001). The patients in DMPA group had significantly less pain scores at 12 weeks after the surgery (p = 0.01). Conclusion: The current study demonstrated that no significant change of IL-1α serum level in women with endometrioma before and after the surgery, with or without postoperative treatment with DMPA. We found decreasing of pain score in both group after surgery and less pain score in DMPA group.
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Thai Journal of Obstetrics and Gynaecology (Jun 2013) Effect of DMPA on IL-1 Alpha in Serum of Women with Endometrioma Abstract Objective: To study the effect of DMPA on serum IL-1α in women with endometrioma undergoing the conservative surgery.Materials and methods:A randomized clinical trial was performed in thirty-five women with endometrioma who underwent conservative surgery in Reproductive Endocrinology and Laparoscopy clinic in Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital. These patients were randomly assigned to one of the following treatments: group A surgery and postoperative treatment with DMPA 150 mg intramuscular or group B surgery alone. Serum IL-1α level was measured by enzyme-linked immunosorbent assay (ELISA) in both groups. Pain scores were evaluated using a visual analog scale (VAS) at 2 and 12 weeks after the operation.Results: There was no significant difference in IL-1α serum levels between both groups at 2 weeks and 12 weeks after the surgery (p = 0.06 and 0.86 respectively). There was no significant difference in pre and postoperative IL-1α level between both group (p = 0.23 and 1.00 respectively). Pain scores of both groups were significantly decreased at 2 weeks and 12 weeks after the surgery (p < 0.001). The patients in DMPA group had significantly less pain scores at 12 weeks after the surgery (p = 0.01). Conclusion: The current study demonstrated that no significant change of IL-1α serum level in women with endometrioma before and after the surgery, with or without postoperative treatment with DMPA. We found decreasing of pain score in both group after surgery and less pain score in DMPA group.

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Outcome instruments

VAS-pain

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endometrioma

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