Immunology of endometriosis

Barrier BF, Breton F. Barrier
Clinical Obstetrics and Gynecology · 2010 · vol. 53(2) , pp. 397–402 · doi:10.1097/GRF.0b013e3181db7c33 · PMID:20436316
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This review examines the association between endometriosis and autoimmune disease, describing how chronic local inflammation may contribute to immunologic self-reactivity in these patients.

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This review examines the immunological mechanisms underlying endometriosis, focusing on the interplay between chronic local inflammation and autoimmune responses. It highlights that symptomatic cases are often linked to progesterone resistance and dysregulated cytokine production within both ectopic and eutopic endometrial tissues. The authors note that this inflammatory environment may drive antibody self-reactivity, citing documented coexistence with autoimmune diseases and the presence of autoreactive antibodies in patient sera. This paper is centrally about endometriosis — specifically exploring its association with autoimmune disease and the role of inflammation in developing immunologic self-reactivity.

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Abstract

Endometriosis is a common condition with a varied phenotype. Symptomatic cases have been associated with progesterone resistance and dysregulated cytokine production in both ectopic and eutopic endometrium. In at least some cases, this seems to be associated with chronic local inflammation and antibody self-reactivity. Coexistence of endometriosis with autoimmune disease has been documented in a small number of cases, and the presence of autoreactive antibodies in the serum of some patients with endometriosis is commonly reported. This paper briefly reviews the association between endometriosis and autoimmune disease and describes the potential role of inflammation in the development of immunologic self-reactivity in these patients.
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Endometriosis Immunology of Endometriosis - BRETON F. BARRIER Endometriosis is a common condition with a varied phenotype. Symptomatic cases have been associated with progesterone resistance and dysregulated cytokine production in both ectopic and eutopic endometrium. In at least some cases, this seems to be associated with chronic local inflammation and antibody self-reactivity. Coexistence of endometriosis with autoimmune disease has been documented in a small number of cases, and the presence of autoreactive antibodies in the serum of some patients with endometriosis is commonly reported. This paper briefly reviews the association between endometriosis and autoimmune disease and describes the potential role of inflammation in the development of immunologic self-reactivity in these patients. Copyright © 2010 Lippincott Williams & Wilkins, Inc.

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Condition tags

endometriosis

MeSH descriptors

Autoimmune Diseases Endometriosis Endometrium Autoantibodies Autoantibodies Autoantibodies Autoimmune Diseases Autoimmune Diseases Endometriosis Endometriosis Endometrium Endometrium Female Female Humans Humans Inflammation Inflammation Inflammation Pregnancy

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