[Role of genetic and environmental factors in the development of endometriosis].

Animals; Endometriosis/epidemiology/etiology/genetics; Environment; Epigenesis, Genetic/physiology; Female; Gene-Environment Interaction; Humans; Risk Factors; Uterine Diseases/epidemiology/etiology/genetics

[en] Endometriosis is usually described as a complex multifactorial disease involving dysregulation of estrogen metabolism, inflammatory and immunological mechanisms. Recently, many authors have questioned the environmental pollution and toxins in the formation and development of endometriotic lesions. Therefore, while dioxins and PCBs have been implicated, insufficient data are available until now to confirm this theory. Endometriosis has also been considered as a genetic disease. Indeed, early familial aggregation and twin studies noted a higher risk of endometriosis among relatives. However, demonstration of a genetic component in the pathogenesis of such a multifactorial disease is quite difficult due to many limitations such as ethnic differences, involvement of environmental factors and size of needed patients cohorts. Over the last decade, the epigenetic approach (DNA methylation, histones modifications and microRNA) has allowed to consider many new perspectives. Indeed, dysregulation (hyper- or hypomethylation) of many genes has already been highlighted. This method of analysis is the subject of numerous studies in order to develop diagnostic, prognostic and therapeutic tools for this disease which is becoming a real public health problem. Disciplines : Reproductive medicine (gynecology, andrology, obstetrics) Ballester, M. Dehan, Pierre ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques BELIARD, Aude ; Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR Brichant, Géraldine ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement Nisolle, Michelle ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique Language : French Title : Le role de la genetique et de l'environnement dans le developpement de l'endometriose. Alternative titles : [en] Role of genetic and environmental factors in the development of endometriosis Publication date : 2012 Journal title : Revue Médicale de Liège ISSN : 0370-629X eISSN : 2566-1566 Publisher : Université de Liège. Revue Médicale de Liège, Liège, Belgium Volume : 67 Issue : 5-6 Pages : 374-80 Peer reviewed : Peer reviewed Available on ORBi : since 12 January 2013 Scopus citations® 12 Scopus citations® without self-citations without self-citations 10 OpenAlex citations 13 - Darai E, Bazot M, Ballester M. - Endometriosis. Revue Prat, 2010, 60, 603-605, 607-609. - Nisolle M, Alvarez ML, Colombo M, et al. - Pathogenesis of endometriosis. Gynecol Obst Fertil, 2007, 35, 898-903. - Fauconnier A, Chapron C, Dubuisson JB, et al. - Relation between pain symptoms and the anatomic location of deep infiltrating endometriosis. 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