Suppression of F-18 fluorodeoxyglucose uptake in benign uterine leiomyomas with danazol

Madhavi Tripathi, Madhur Kumar Srivastava, Madhur Srivastava, Gunjun Garg, Abhinav Jaimini, Namita Singh, Maria do Carmo Custódio de Souza, Maria D Souza, Prabhjot Kaur, Rajnish Sharma, Anupam Mandal
Clinical nuclear medicine · 2009 · vol. 34(7) , pp. 452–455 · doi:10.1097/rlu.0b013e3181a7d02a · PMID:19542955 · W2014266684
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Danazol treatment of a uterine leiomyoma in a patient previously treated for Hodgkin lymphoma resulted in the complete disappearance of F-18 FDG uptake on a repeat PET-CT scan.

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Abstract

A 40-year premenopausal woman was referred by her treating oncologist for F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to rule out disease recurrence or metastasis. She had completed therapy for Hodgkin lymphoma (Stage IIA) 1 year earlier. Post-therapy gallium-67 study showed no evidence of residual disease and the patient was on regular follow-up. The only abnormality detected on the FDG-PET/CT study was a focus of abnormal FDG accumulation in the pelvis, suprapubically. Fused PET-CT localized the uptake to the uterine myometrium in the fundal region posteriorly corresponding to mild inhomogeneity in attenuation with a bulky uterus on CT. MRI of the pelvis confirmed the presence of a uterine leiomyoma in the fundal region. The patient was put on danazol (200 mg twice daily for 14 days) and a repeat PET-CT of the pelvis was done after 14 days, which revealed complete disappearance of FDG uptake in the leiomyoma. This proved that F-18 FDG uptake in the leiomyoma was probably related to its vascularity.

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MeSH descriptors

Danazol Estrogen Antagonists Fluorodeoxyglucose F18 Leiomyoma Uterine Neoplasms Adult Danazol Estrogen Antagonists Female Fluorodeoxyglucose F18 Humans Leiomyoma Leiomyoma Leiomyoma Myometrium Myometrium Myometrium Myometrium Positron-Emission Tomography Radiopharmaceuticals

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