Progress of the study of pericytes and their potential research value in adenomyosis

Chenyu Zhang, Jinghua Shi, Yi Dai, Xiaoyan Li, Jinhua Leng
Science progress · 2024 · vol. 107(2) , pp. 368504241257126 · doi:10.1177/00368504241257126 · PMID:38863331 · W4399589228
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This review explores pericyte markers, their roles in angiogenesis and fibrosis, and their potential connections to the pathophysiology and development of adenomyosis.

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Abstract

Pericytes (PCs) are versatile cells integral to the microcirculation wall, exhibiting specific stem cell traits. They are essential in modulating blood flow, ensuring vascular permeability, maintaining homeostasis, and aiding tissue repair process. Given their involvement in numerous disease-related pathological and physiological processes, the regulation of PCs has emerged as a focal point of research. Adenomyosis is characterized by the presence of active endometrial glands and stroma encased by an enlarged and proliferative myometrial layer, further accompanied by fibrosis and new blood vessel formation. This distinct pathological condition might be intricately linked with PCs. This article comprehensively reviews the markers associated with PCs, their contributions to angiogenesis, blood flow modulation, and fibrotic processes. Moreover, it provides a comprehensive overview of the current research on adenomyosis pathophysiology, emphasizing the potential correlation and future implications regarding PCs and the development of adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Pericytes Pericytes Pericytes Pericytes Animals Animals Animals Biomarkers Biomarkers Biomarkers Biomarkers Endometrium Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
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pubmed
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License: CC0 · commercial use OK