Effects of danazol on DNA synthesis in submaxillary glands of male rats

S. Sakamoto, K Sawaki, Shinya Suzuki, S Suzuki, Hideki Kudo, H Kudo, Takehiko Mori, T Mori, H. Nagasawa, Hideko Nagasawa
In vivo (Athens, Greece) · 1992 · vol. 6(2) , pp. 141–3 · PMID:1525333 · W2415222027
Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation
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Danazol administration reduced luteinizing hormone, testosterone, and S-phase cells in male rat submaxillary glands, indicating antiandrogenic or antigonadotrophic activity.

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Abstract

Danazol is an isoxazol derivative of the synthetic steroid, 17 alpha-ethinyltestosterone (ethisterone). Intragastric administration of danazol (10 mg/100 g body weight) markedly reduced plasma levels of luteinizing hormone and testosterone, and the number of S-phase cells labelled with bromodeoxyuridine (BrdU) in the submaxillary glands which were androgen-dependent in adult male rats. These results demonstrated that danazol might show a potency as antiandrogenic and/or antigonadotrophic agent.

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MeSH descriptors

Androgen Antagonists Danazol DNA Replication Submandibular Gland Androgen Antagonists Animals Cell Division Cell Division Danazol DNA Replication Follicle Stimulating Hormone Follicle Stimulating Hormone Luteinizing Hormone Luteinizing Hormone Male Rats Rats, Inbred Strains Submandibular Gland Submandibular Gland Testosterone

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