A randomized trial of danazol pretreatment prior to endometrial resection

Alka Kriplani, Ranjit Manchanda, Jyoti Nath, Deep Takkar
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2002 · vol. 103(1) , pp. 68–71 · doi:10.1016/s0301-2115(02)00012-x · PMID:12039468 · W1981143180
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This randomized trial evaluated the efficacy of danazol pretreatment in reducing operative blood loss and improving surgical outcomes for patients undergoing endometrial resection.

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Abstract

OBJECTIVES: To assess the effect of danazol pretreatment in women undergoing endometrial resection for dysfunctional uterine bleeding. STUDY DESIGN: A total of 132 patients were randomly divided into danazol pretreated and untreated groups. Endometrial resection was carried out using a 24Fr cutting wire loop electrode and 1.5% glycine as the distension media. Patients were followed-up for 6 years. The t-test and Chi-square tests were used to test differences between the two groups. RESULTS: The mean endometrial thickness, fluid used, fluid deficit, weight of resected tissue and duration of surgery were significantly greater in the unprepared group. Over 70% of patients in both the groups achieved amenorrhoea or spotting. Two (1.5%) patients underwent a repeat procedure and two (1.5%) others a hysterectomy, while the rest had hypomenorrhoea. The perimenstrual symptoms also showed significant improvement. No statistically significant difference was found in the outcomes of the two groups. CONCLUSION: Endometrial resection is an effective alternative to hysterectomy and pretreatment of the endometrium is not necessary for good outcomes.

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MeSH descriptors

Danazol Endometrium Estrogen Antagonists Premedication Adult Biopsy Danazol Endometrial Hyperplasia Endometrial Hyperplasia Endometrial Hyperplasia Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrium Endometrium Estrogen Antagonists Female Humans Hysterectomy Hysteroscopy

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