What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility

Zhouyurong Tan, Sze Wan Hung, Xu Zheng, Zheng Xu, Chi Chiu Wang, Jacqueline Pui-Wah Chung, Jacqueline Pui Wah Chung, Tao Zhang
Biomedicines · 2022 · vol. 10(7) , pp. 1483 · doi:10.3390/biomedicines10071483 · PMID:35884788 · W4283326945
review OA: gold CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review summarizes investigations into endometrioma-related infertility using animal models to explore pathogenesis and identify potential therapeutic targets.

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Abstract

Endometrioma (OMA) is the most common subtype of endometriosis, in which the endometriotic lesions are implanted in the ovary. Women with OMA are usually associated with infertility, presenting with reduced ovarian reserve, low oocyte quantity and quality, and poor fertility outcomes. However, the underlying pathological mechanisms in OMA-related infertility are still unclear. Due to the limitations and ethical issues of human studies in reproduction, animal models that recapitulate OMA characteristics and its related infertility are critical for mechanistic studies and subsequent drug development, preclinical testing, and clinical trials. This review summarized the investigations of OMA-related infertility based on previous and latest endometrioma models, providing the possible pathogenesis and potential therapeutic targets for further studies.

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endometriosisendometriomainfertility

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