Immune rosettes of T and B lymphocytes in infertile women with endometriosis

S Z Badawy, Shawky Z.A. Badawy, Badawy Sz, Cuenca V, V Cuenca, Ann Stitzel, A Stitzel, Stitzel A, D Tice, Tice D, Diane G. Tice
The Journal of reproductive medicine · 1987 · vol. 32(3) , pp. 194–7 · PMID:3494842 · W2417905617
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This study found increased T and B lymphocytes and a higher T4:T8 ratio in the peritoneal fluid and peripheral blood of infertile women with endometriosis compared to controls.

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Abstract

We examined the cell-mediated immune response in women with pelvic endometriosis by quantitating their T and B lymphocytes. The study was conducted on heparinized peripheral blood and peritoneal fluid. The results were compared with those in a control group of women without evidence of endometriosis. Each patient underwent laparoscopy as part of her infertility evaluation. The ability of T cells to form rosettes with sheep erythrocytes was used to estimate the percentage of total and active T cells. B lymphocytes were quantitated by erythrocyte antibody complement binding capacity. In addition, T and B lymphocytes were assayed with the Immunobead technique using specific monoclonal antibodies. The helper T cell (T4) and suppressor T cell (T8) subsets of lymphocytes were evaluated with specific monoclonal antibodies coupled to microbeads. The results demonstrated an increased number of T and B cells in peritoneal fluid and peripheral blood from patients with endometriosis as compared with controls. Furthermore, the ratio T4:T8 was significantly increased in patients with endometriosis. These results suggest a cell-mediated immune response in the presence of endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Autoimmune Diseases B-Lymphocytes Endometriosis Infertility, Female Pelvic Neoplasms Rosette Formation Rosette Formation T-Lymphocytes Autoimmune Diseases Autoimmune Diseases B-Lymphocytes B-Lymphocytes Endometriosis Endometriosis Female Female Humans Humans Infertility, Female Infertility, Female

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