Effect of long-term hormone replacement therapy on the bone in ovariectomized women with cancer

Takumi Kurabayashi, T Kurabayashi, Tetsuro Yahata, T Yahata, A Honda, Akira Honda, M Tomita, Manabu Tomita, M Yasuda, Masahiro Yasuda, Takayuki Tanaka, T Tanaka
International Journal of Gynecology & Obstetrics · 1998 · vol. 60(3) , pp. 271–277 · doi:10.1016/s0020-7292(97)00272-5 · PMID:9544712 · W2074089512
Non-randomised trial OA: closed CC0 ⤵ 2 in-corpus citations
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Long-term hormone replacement therapy preserved bone mineral density and lowered alkaline phosphatase levels for five years in ovariectomized women with gynecologic malignancies compared to untreated patients.

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Abstract

OBJECTIVE: To evaluate longitudinally the effectiveness of long-term hormone replacement therapy (HRT) in preserving the bone mineral density (BMD) over a 5-year period in ovariectomized patients treated for gynecologic malignancies. METHODS: A total of 70 pre-menopausal women ovariectomized for gynecologic malignancies at our hospital were divided non-randomly into two groups: HRT (+) group (n = 59) and HRT (-) group (n = 11). HRT was administered in a sequential regimen of 0.625-1.25 mg conjugated estrogen for 24 days and 5-10 mg medroxyprogesterone acetate for 10 days. RESULTS: The BMD of the lumbar vertebrae decreased significantly in the HRT (-) group (pre-operative BMD was 91.8%, 91.0% and 91.3% at 1, 2 and 3 years post-ovariectomy), but no decrease in the BMD was observed in the HRT (+) group (pre-operative BMD was 98.4%, 99.0%, 99.4%, 98.8% and 98.7% at 1, 2, 3, 4 and 5 years post-ovariectomy); the difference in BMD between the two groups was statistically significant (P < 0.01). Serum alkaline phosphatase levels were significantly lower in the HRT (+) group than in the HRT (-) group (P < 0.01). There were four recurrences of cancer in the HRT (+) group. CONCLUSION: HRT appeared to have beneficial effects on bone metabolism by maintaining BMD for 5 years in ovariectomized patients for gynecologic malignancies.

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MeSH descriptors

Bone Density Estrogen Replacement Therapy Genital Neoplasms, Female Genital Neoplasms, Female Ovariectomy Adult Alkaline Phosphatase Alkaline Phosphatase Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Female Genital Neoplasms, Female Genital Neoplasms, Female Humans Longitudinal Studies Middle Aged Neoplasm Recurrence, Local Ovarian Neoplasms

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