Vascular endothelial growth factor gene polymorphism as a risk factor of endometriosis

Ahmed Magdy, Khaled N. Abd-El Razik, Hisham Hamza, Hisham S. Hamza, Wael El-Garf, Waleed S. Abd-Elgaber
In: Evidence Based Womenʼs Health Journal · 2014 · vol. 4(2) , pp. 92–95 · doi:10.1097/01.ebx.0000440892.99947.19 · W2327555944
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The +405G>C polymorphism of the vascular endothelial growth factor gene was associated with endometriosis risk in Egyptian women but not with disease severity.

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This case-control study investigated the association between the +405G>C single-nucleotide polymorphism in the vascular endothelial growth factor gene and endometriosis risk among 100 Egyptian women. Researchers compared genotype frequencies in 50 patients with laparoscopically confirmed endometriosis against 50 healthy controls using real-time Taqman-based assays. The results indicated a significant difference in both genotype and allele frequencies, suggesting that this specific polymorphism is associated with an increased risk of developing the disease. However, the study found no significant correlation between these genetic variations and the severity or stage of endometriosis. This paper is centrally about endometriosis — specifically examining a genetic risk factor for its development.

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Abstract

Objective The aim of the study was to investigate the potential association between the single-nucleotide polymorphism (SNP) +405G>C of the vascular endothelial growth factor gene with the risk of endometriosis. Materials and methods This study included 100 Egyptian women, 50 women with and 50 women without evidence of endometriosis, who were tested for association in a case–control study. Endometriosis was diagnosed by direct visualization of implants by laparoscopy and classified into stages according to the Revised American Fertility Society (R-AFS) classification (1996). Venous blood samples (EDTA) of 8 ml were taken from the peripheral blood of each individual. Genotyping for the +405G>C polymorphism was performed using real-time Taqman-based assays (SNP ID rs2010963). Results There was a significant difference in the genotype [P<0.05, odds ratio=5.2 (1.66–16.6)] and allele frequencies [P<0.05, odds ratio=2.45 (1.35–4.47)] of the +405C/G polymorphism among endometriosis patients as compared with controls. However, there was no significant difference between early-stage and advanced-stage endometriosis patients versus controls in terms of +405G/C genotype distributions. Conclusion There seems to be an association between the vascular endothelial growth factor gene polymorphism and the risk of endometriosis but not with its severity.
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Objective

The aim of the study was to investigate the potential association between the single-nucleotide polymorphism (SNP) +405G>C of the vascular endothelial growth factor gene with the risk of endometriosis.

Materials and methods

This study included 100 Egyptian women, 50 women with and 50 women without evidence of endometriosis, who were tested for association in a case–control study. Endometriosis was diagnosed by direct visualization of implants by laparoscopy and classified into stages according to the Revised American Fertility Society (R-AFS) classification (1996). Venous blood samples (EDTA) of 8 ml were taken from the peripheral blood of each individual. Genotyping for the +405G>C polymorphism was performed using real-time Taqman-based assays (SNP ID rs2010963).

Results

There was a significant difference in the genotype [P<0.05, odds ratio=5.2 (1.66–16.6)] and allele frequencies [P<0.05, odds ratio=2.45 (1.35–4.47)] of the +405C/G polymorphism among endometriosis patients as compared with controls. However, there was no significant difference between early-stage and advanced-stage endometriosis patients versus controls in terms of +405G/C genotype distributions.

Conclusion

There seems to be an association between the vascular endothelial growth factor gene polymorphism and the risk of endometriosis but not with its severity.

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endometriosis

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