Pharmacological treatment of endometriosis: update from recent clinical trials
article
OA: closed
CC0
Abstract
Endometriosis is a chronic disease that causes pain and infertility. Combined oral contraceptives and progestins are commonly used for the treatment of endometriosis because they reduce the severity of pain symptoms in 60–70% of patients and are well tolerated. Gonadotropin-releasing hormone analogs and danazol may be administered to selected patients but their long-term use is limited owing to the high frequency of severe adverse effects. Aromatase inhibitors should be administered only to women who fail to improve after surgery and conventional hormonal therapy because they are not well tolerated. This article discusses the medical therapies available for the treatment of endometriosis-related pain symptoms; in addition, detailed information on the recent advances in the treatment of rectovaginal endometriosis, ovarian endometriomas and bowel endometriosis is presented.
My notes (saved in your browser only)
Condition tags
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (76)
- Anastrazole and oral contraceptives: a novel treatment for endometriosis via openalex
- Antiangiogenic therapies in endometriosis via openalex
- Aromatase expression in endometriosis via openalex
- Aromatase expression in endometriosis. via openalex
- Bowel Endometriosis: Presentation, Diagnosis, and Treatment via openalex
- Changes in quality of life after hormonal treatment of endometriosis via openalex
- Changes in quality of life after hormonal treatment of endometriosis via openalex
- Clinical and quality-of-life outcomes after fertility-sparing laparoscopic surgery with bowel resection for severe endometriosis via openalex
- Current pharmacotherapy for endometriosis via openalex
- Danazol for pelvic pain associated with endometriosis via openalex
- Decrease in the size of ovarian endometriomas during ovarian suppression in stage IV endometriosis. Role of preoperative medical treatment. via openalex
- Deep dyspareunia and sex life after laparoscopic excision of endometriosis via openalex
- Detection of aromatase cytochrome P-450 in endometrial biopsy specimens as a diagnostic test for endometriosis via openalex
- Diagnosis of bowel endometriosis: A review via openalex
- Diagnosis of Bowel Endometriosis: A Review via openalex
- Effects of Triptorelin Versus Placebo on the Symptoms of Endometriosis via openalex
- [Efficacy of duphaston treatment in women with endometriosis after reconstructive surgery]. via openalex
- Efficacy of vaginal danazol treatment in women with recurrent deeply infiltrating endometriosis via openalex
- Endometriosis in postmenopausal women without previous hormonal therapy: report of three cases via openalex
- Endometriosis: Treatment Strategies via openalex
- Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1 via openalex
- Future Perspectives in the Medical Treatment of Endometriosis via openalex
- Gestrinone versus a gonadotropin-releasing hormone agonist for the treatment of pelvic pain associated with endometriosis: a multicenter, randomized, double-blind study via openalex
- Gonadotropin-releasing hormone agonist treatment for endometriosis of the rectovaginal septum via openalex
- Health-related quality of life burden of women with endometriosis: a literature review via openalex
- Intrauterine progestins, progesterone antagonists, and receptor modulators: a review of gynecologic applications via openalex
- Laparoscopic excision of endometriosis: A randomized, placebo-controlled trial via openalex
- Laparoscopic surgery for pelvic pain associated with endometriosis via openalex
- Letrozole and desogestrel‐only contraceptive pill for the treatment of stage IV endometriosis via openalex
- Letrozole and norethisterone acetate in colorectal endometriosis via openalex
- Letrozole and norethisterone acetate in rectovaginal endometriosis via openalex
- Long-acting triptorelin for the treatment of endometriosis via openalex
- Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial via openalex
- Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis via openalex
- Management of ovarian endometriomas via openalex
- Medical treatment for rectovaginal endometriosis: what is the evidence? via openalex
- Norethisterone acetate in the treatment of colorectal endometriosis: a pilot study via openalex
- Patients' report on how endometriosis affects health, work, and daily life via openalex
- Pentoxifylline After Conservative Surgery for Endometriosis: A Randomized, Controlled Trial via openalex
- Pentoxifylline versus medical therapies for subfertile women with endometriosis via openalex
- Pharmacological Treatment of Endometriosis via openalex
- Postoperative administration of monophasic combined oral contraceptives after laparoscopic treatment of ovarian endometriomas: A prospective, randomized trial via openalex
- Postoperative oral contraceptive exposure and risk of endometrioma recurrence via openalex
- Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision via openalex
- Prevalence of newly diagnosed endometriosis in women attending the general practitioner via openalex
- Progression of bowel endometriosis during treatment with the oral contraceptive pill via openalex
- Quality of sex life in women with endometriosis and deep dyspareunia via openalex
- Role of the vaginally administered aromatase inhibitor anastrozole in women with rectovaginal endometriosis: a pilot study via openalex
- Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis via openalex
- Surgical outcome and long‐term follow up after laparoscopic rectosigmoid resection in women with deep infiltrating endometriosis via openalex
- Surgical Treatment of Endometriosis via openalex
- The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial via openalex
- The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex
- The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease via openalex
- The place of dydrogesterone in the treatment of endometriosis and adenomyosis via openalex
- Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil via openalex
- Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex
- Triptorelin improves intestinal symptoms among patients with colorectal endometriosis via openalex
- Unusual complication of excision of pelvic endometriosis: pseudoaneurysm of the left uterine artery via openalex
- Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis via openalex
- Uterine adenomyosis in persistence of dysmenorrhea after surgical excision of pelvic endometriosis and colorectal resection. via openalex
- Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device via openalex
- Vaginal danazol in women with rectovaginal endometriosis and pain symptoms persisting after the insertion of the levonorgestrel-releasing intrauterine device via openalex
- Zoladex (goserelin acetate implant) in the treatment of endometriosis: a randomized comparison with danazol. The Zoladex Endometriosis Study Group. via openalex
- W2045089102 via openalex
- W2039905178 via openalex
- W2024432286 via openalex
- W1966609815 via openalex
- W4285719527 via openalex
- W2135754669 via openalex
- W2123134517 via openalex
- W2096980318 via openalex
- W2066865081 via openalex
- W2157853773 via openalex
- W2046911682 via openalex
- W2159803441 via openalex
Source provenance
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- unpaywall
- last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0
· commercial use OK