Skeletal alterations in ovariectomized rats

Thomas J. Wronski, T J Wronski, P. L. Lowry, C. C. Walsh, L. A. Ignaszewski
Calcified tissue international · 1985 · vol. 37(3) , pp. 324–328 · doi:10.1007/bf02554882 · PMID:3926284 · W1972376518
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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Ovariectomy in female rats induced significant trabecular bone loss and accelerated skeletal metabolism, characterized by elevated osteoclast and osteoblast activity alongside increased longitudinal bone growth.

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Abstract

Female Sprague Dawley rats were subjected to either bilateral ovariectomy or sham surgery. Tetracycline derivatives were administered to each rat on two separate occasions to label sites of bone formation. All rats were sacrificed at 5 weeks postovariectomy and their proximal tibiae were processed undecalcified for quantitative bone histomorphometry. A twofold decrease in trabecular bone volume was noted in the proximal tibial metaphysis of ovariectomized rats. This bone loss was associated with elevated histomorphometric indices of bone resorption and formation. Ovariectomy increased osteoclast surface and numbers as well as osteoblast surface and numbers. Elevations in calcification rate and fractional trabecular bone surface with double tetracycline labels also suggest that bone formation was stimulated in ovariectomized rats. In addition, ovariectomized rats exhibited a greater rate of longitudinal bone growth relative to sham-operated control rats. These histomorphometric data indicate that ovariectomy induces marked bone loss and accelerated skeletal metabolism in rats.

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MeSH descriptors

Bone and Bones Bone Development Bone Resorption Castration Animals Body Weight Bone and Bones Bone and Bones Bone and Bones Female Osteoblasts Osteoblasts Osteoclasts Osteoclasts Ovary Ovary Rats Tetracycline

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