Genotype and allele distributions of SNPs surrounding miRNA target site of BMPR1B in endometriosis patients and controls.

Cherry Yin-Yi Chang (493833), Yi Chen (38576), Ming-Tsung Lai (493834), Hui-Wen Chang (209955), Jack Cheng (493835), Carmen Chan (493836), Chih-Mei Chen (309456), Shan-Chih Lee (493837), Ying-Ju Lin (419103), Lei Wan (290406), Pei-Wen Tsai (227589), Su-Han Yang (493838), Ching Chung (493839), Jim Jinn-Chyuan Sheu (493840), Fuu-Jen Tsai (230856)
2015 · doi:10.1371/journal.pone.0080630.t001 · W6941965016
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Researchers analyzed genotype and allele distributions of SNPs surrounding the miRNA target site of BMPR1B in endometriosis patients and controls using chi-squared tests.

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This study investigated the association between single nucleotide polymorphisms located near the microRNA binding site of the BMPR1B gene and susceptibility to endometriosis. Researchers compared genotype and allele distributions in patients with endometriosis against control subjects to determine if specific genetic variations influenced disease risk. The findings indicated that up-regulation of BMPR1B due to variations in this miRNA target site defines endometriosis susceptibility and correlates with CA125 levels. This paper is centrally about endometriosis, focusing on genetic markers associated with disease susceptibility and biomarker expression.

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Abstract

aGenotype and allele distributions were analyzed by χ2 test.Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.
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BMPR1B Up-Regulation via a miRNA Binding Site Variation Defines Endometriosis Susceptibility and CA125 Levels Table 1 Genotype and allele distributions of SNPs surrounding miRNA target site of BMPR1B in endometriosis patients and controls. Skip to main content Advertisement Browse Subject Areas ? Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click here. Genotype and allele distributions of SNPs surrounding miRNA target site of BMPR1B in endometriosis patients and controls.

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endometriosis

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