The influence of mifepristone to caspase 3 expression in adenomyosis

Yushan Wang, Y Wang, Xinwei Jiang, X Jiang, S Wang
Clinical and experimental obstetrics & gynecology · 2014 · vol. 41(2) , pp. 154–157 · doi:10.12891/ceog15872014 · PMID:24779241 · W1466955774
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Abstract

OBJECTIVE: To discuss the influence of mifepristone to caspase 3 expression in adenomyosis tissue. MATERIALS AND METHODS: Sixty patients were equally divided into four groups. Groups 1, 2, and 3 were treated with 5, 10, and 15 mg mifepristone, respectively and group 4 was treated with placebo. The expression of caspase 3 was examined by immunohistochemical method in both eutopic and ectopic endometria of the 40 cases. RESULTS: Compared with placebo group, the expression of caspase 3 in both eutopic endometrium and ectopic endometrium in the three treatment groups was significantly increased. There was no difference in the expression of caspase 3 in both eutopic and ectopic endometria between the ten and 25 mg treatment groups, while both the ten and 25 mg treatment groups had a higher expression intensity of caspase 3 in both eutopic and ectopic endometria, compared with the five mg treatment group (p < 0.01). CONCLUSION: Mifepristone can increase the expression of caspase 3 in both eutopic and ectopic endometria and initiate cell apoptosis in both eutopic and ectopic endometria. Therefore mifepristone can effectively inhibit the emergence and development of adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Caspase 3 Endometrium Hormone Antagonists Mifepristone Adenomyosis Adenomyosis Adult Caspase 3 Dose-Response Relationship, Drug Endometrium Female Hormone Antagonists Humans Immunohistochemistry Middle Aged Mifepristone

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