Cyclooxygenase-2 overexpression in ovarian endometriomas is associated with higher risk of recurrence

Lei Yuan, Yuan L, Shen F, Fanghua Shen, Yuan Lu, Xishi Liu, Liu X, Sun-Wei Guo, Sun‐Wei Guo, Guo SW
Fertility and sterility · 2008 · vol. 91(4) , pp. 1303–1306 · doi:10.1016/j.fertnstert.2008.01.070 · PMID:18367179 · W2031190138
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Ovarian endometriomas with higher cyclooxygenase-2 expression were associated with an increased risk of recurrence.

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Abstract

Cyclooxegenase-2 expression was evaluated by immunohistochemistry in endometrioma tissue samples taken from 109 patients, of whom 53 had recurrence by 30 months after surgery and 56 did not. Cyclooxegenase-2 overexpression, along with previous medical treatment of endometriosis and the presence of adhesion, is predictive of recurrence of ovarian endometrioma within 30 months after surgery, with a resultant sensitivity of 72.5% and a specificity of 72.4%, suggesting that there are intrinsic and identifiable biomarkers that confer recurrence risk.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Adult Adult Biomarkers Biomarkers Biomarkers Case-Control Studies Case-Control Studies Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Female Female Gene Expression Regulation, Enzymologic

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (28)

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