Pharmacokinetic study of single and multiple oral administrations of 2 mg dienogest in healthy Korean women

Shin D, Donghoon Shin, SeungHwan Lee, Lee S, Kyoung Soo Lim, Lim KS, Joong Shin Park, Shin SG, Sang-Goo Shin, In-Jin Jang, Jang IJ, In‐Jin Jang, Kyung-Sang Yu, Kyung‐Sang Yu
Contraception · 2012 · vol. 87(6) , pp. 750–755 · doi:10.1016/j.contraception.2012.10.033 · PMID:23218856 · W1998545834
Non-randomised trial OA: closed CC0 ⤵ 7 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This study investigated the pharmacokinetics of single and multiple oral doses of 2 mg dienogest in healthy Korean women.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: The progestin dienogest was developed for oral contraception, endometriosis treatment and menopause management. Dienogest's pharmacokinetics have been primarily studied in Caucasian women. This study evaluated the single- and multiple-dose pharmacokinetics of dienogest in Korean women. STUDY DESIGN: Sixteen healthy Korean adult women received a single administration of 2 mg dienogest, followed by multiple once-daily administrations for 14 days. The single-dose administration and the final dose of the multiple administrations were each followed by blood sampling over 60 h. RESULTS: The mean (SD) maximum serum concentration after multiple doses of dienogest was slightly increased compared with that after a single dose [from 51.6 (9.6) to 56.6 (11.9) ng/mL], as was the area under the concentration-time curves (AUC)0-24h [from 503 (56.3) to 613 (90.7) ng ∙ h/mL]. The linearity factor calculated by AUCs of single and multiple doses is 1.00 ± 0.14, and the terminal half-life remained unchanged when single dosing and multiple dosing were compared. CONCLUSIONS: The present study described the single- and multiple-dose pharmacokinetic profiles of dienogest in Korean women and showed linear pharmacokinetics of dienogest at steady state.

My notes (saved in your browser only)

MeSH descriptors

Contraceptives, Oral Nandrolone Progestins Administration, Oral Administration, Oral Adult Adult Contraceptives, Oral Contraceptives, Oral Contraceptives, Oral Contraceptives, Oral Contraceptives, Oral Female Female Half-Life Half-Life Humans Humans Metabolic Clearance Rate Metabolic Clearance Rate

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (17)

Cited by (6)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-05-11T06:39:27.580236+00:00
pubmed
last seen: 2026-10-08T21:11:10.042802+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK