Nerve fibers in endometriosis: pain pathogenesis and new approaches to diagnosis

L.V. Adamyan, М. М. Сонова, O. V. Paklina, E.A. Karapetyan, K. N. Arslanyan
In: Russian Journal of Human Reproduction · 2026 · vol. 32(2) , pp. 54 · doi:10.17116/repro20263202154 · W7156197642
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review analyzes the role of PGP 9.5 as a marker for nerve fibers in endometriosis pain pathogenesis and diagnosis, highlighting its potential and current limitations for clinical use.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper reviews how nerve fibers contribute to endometriosis-associated pain pathogenesis and discusses emerging diagnostic approaches, focusing on evidence from histological/immunohistochemical studies and biomarker concepts. It summarizes findings that suggest increased or altered innervation in endometriotic lesions (especially deep infiltrating lesions) and in some relevant tissue layers, linking these neural changes with pain mechanisms such as peripheral sensitization and hyperalgesia. A key limitation is that the evidence base and diagnostic performance vary across studies and tissue sampling approaches, and the review format does not provide uniform, pooled effectiveness estimates. This paper is centrally about endometriosis — it focuses specifically on nerve fibers in endometriosis pain pathogenesis and new diagnostic approaches.

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Abstract

Genital endometriosis is a chronic multisystem disease in which pain syndrome remains the leading clinical manifestation. Despite significant advances in understanding the pathogenesis of endometriosis, the mechanisms of pain generation and the reasons for the discrepancy between the extent of morphological lesions and the severity of clinical symptoms remain the subject of active investigation. In recent years, increasing attention has been paid to the role of nerve fibers and neuroimmune interactions in the development of endometriosis-associated pain. The aim of this review is to analyze current data on the role of protein gene product 9.5 (PGP 9.5) as an immunohistochemical marker of nerve fibers in the pathogenesis of pain syndrome and in the diagnosis of endometriosis. The review addresses contemporary concepts of neuronal and neuroimmune mechanisms of pain, features of innervation of the eutopic endometrium and endometriotic lesions, as well as the potential for nerve fiber detection using PGP9.5. Particular emphasis is placed on data regarding the association between nerve fiber density and pain severity, as well as on the prospects for the use of this marker in minimal and early forms of the disease. The analysis of the literature indicates that PGP9.5 is a sensitive and biologically substantiated marker reflecting the neuronal component of endometriosis. At the same time, its use in clinical practice is limited by methodological heterogeneity among studies, the lack of standardized protocols for quantitative assessment, and the absence of universal diagnostic thresholds. At present, PGP9.5 should be regarded as an auxiliary and research tool, the application of which is feasible within comprehensive diagnostic algorithms. Further studies aimed at standardizing methodologies and validating diagnostic criteria are required to clarify the clinical relevance of this approach.
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Сайт издательства «Медиа Сфера» содержит материалы, предназначенные исключительно для работников здравоохранения. Закрывая это сообщение, Вы подтверждаете, что являетесь дипломированным медицинским работником или студентом медицинского образовательного учреждения. Результаты поиска: 0 Нервные волокна при эндометриозе: патогенез боли и новые подходы к диагностике Журнал: Проблемы репродукции. 2026;32(2): 54‑62 Прочитано: 212 раз Как цитировать: Литература / References: - Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstetrics and Gynecology Clinics of North America. 1997;24(2):235-258. https://doi.org/10.1016/S0889-8545(05)70302-8 - Адамян Л.В., Андреева Е.Н. Эндометриоз и его глобальное воздействие на организм женщины. Проблемы репродукции. 2022;28(1):54-64. https://doi.org/10.17116/repro20222801154 - Hadfield R, Mardon H, Barlow DH, Kennedy S. Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK. 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Medical Science Monitor. 2011;17(4):RA92-RA99. https://doi.org/10.12659/MSM.881707 Подтверждение e-mail На [email protected] отправлено письмо со ссылкой для подтверждения e-mail. Перейдите по ссылке из письма, чтобы завершить регистрацию на сайте. Подтверждение e-mail Мы используем файлы cооkies для улучшения работы сайта. Оставаясь на нашем сайте, вы соглашаетесь с условиями использования файлов cооkies. Чтобы ознакомиться с нашими Положениями о конфиденциальности и об использовании файлов cookie, нажмите здесь.

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