Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment

Endah Rahmawati, Wei-Chung Vivian Yang, Wei‐Chung Vivian Yang, Yen-Ping Lei, Pawan Kumar Maurya, Huei‐Wen Chen, Huei-Wen Chen, Chii‐Ruey Tzeng
International journal of molecular sciences · 2019 · vol. 20(18) , pp. 4352 · doi:10.3390/ijms20184352 · PMID:31491902 · W2972026839
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Gonadotropin-releasing hormone agonist treatment significantly decreased neuritin 1 mRNA, protein, and serum levels in women with ovarian endometriosis compared to untreated individuals.

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Abstract

This study aimed to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) treatment on the expression of neuritin 1 (NRN1) in women with ovarian endometriosis. We collected tissues and serum from women with endometriosis treated with (n = 45) or without (n = 37) GnRHa. NRN1 mRNA and protein levels were measured using qPCR and Western blot. Immunolocalization of NRN1 in endometriotic tissues was examined using immunohistochemistry. In addition, a follow-up study was carried out to monitor the serum level of NRN1 in patients before and after GnRHa treatment. Both mRNA (p = 0.046) and protein (p = 0.0155) levels of NRN1 were significantly lower in endometriotic tissues from patients receiving GnRHa treatment compared to the untreated group. Both epithelial and stromal cells of endometriotic tissues from untreated women with endometriosis exhibited stronger staining of NRN1 but not in those who were treated with GnRHa. The follow-up study showed that the serum level of the NRN1 concentration decreased significantly from 1149 ± 192.3 to 379.2 ± 80.16 pg/mL after GnRHa treatment (p = 0.0098). The expression of NRN1 was significantly lower in women with ovarian endometriosis treated with GnRHa. These results suggest that NRN1 may be a biomarker response to the effect of GnRHa treatment for patients with ovarian endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Gonadotropin-Releasing Hormone Neuropeptides Ovary Adult Biomarkers Biopsy Endometriosis Endometriosis Endometriosis Female Gene Expression Gene Expression Regulation Gene Expression Regulation Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone Gonadotropin-Releasing Hormone GPI-Linked Proteins

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