Expression patterns of the steroid receptor coactivator family in human ovarian endometriosis

Atsuko Kumagami, Kumagami A, Akiko Ito, Ito A, Yoshida-Komiya H, Hiromi Yoshida-Komiya, Hiromi Yoshida‐Komiya, Keiya Fujimori, Fujimori K, Sato A, Akira Sato
Journal of Obstetrics and Gynaecology Research · 2011 · vol. 37(10) , pp. 1269–1276 · doi:10.1111/j.1447-0756.2010.01509.x · PMID:21518137 · W1509408671
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This study found that steroid receptor coactivator-1 (SRC-1) is predominantly expressed in ovarian endometriosis and colocalizes with estrogen receptor α, suggesting a role in estrogen receptor transcriptional activity.

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Abstract

AIM: Endometriosis is an estrogen-dependent disease that causes pelvic pain and infertility. In this study, to examine the estrogen-dependent mechanisms of human endometriosis, we focused on the expression patterns of the steroid receptor coactivator (SRC) family of cofactors for nuclear steroid receptors and estrogen receptor α (ERα). MATERIAL AND METHODS: The expression patterns of SRC-1, transitional intermediary factor 2 (TIF2), SRC-3, and ERα, were analyzed by immunohistochemistry of normal endometrium and ovarian endometriotic tissue. In addition, reverse transcription polymerase chain reaction (RT-PCR) for the SRCs was performed for ovarian endometriosis. RESULTS: SRCs were expressed in all examined tissues. The expression levels of SRC-1 and the number of SRC-1-positive cells in ovarian endometriosis were greater than those of TIF2 and SRC-3. In addition, immunohistochemistry showed that ERα was colocalized with SRC-1 in almost all glandular and many stromal cells in ovarian endometriotic tissue. CONCLUSION: The present study demonstrates the expression pattern of SRCs in ovarian endometriosis. It appears that SRC-1 is predominant among the other SRC family members and colocalizes with ERα. Although further study is needed, SRC-1 may affect the transcriptional activity of ERα in human ovarian endometriosis.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Nuclear Receptor Coactivator 1 Nuclear Receptor Coactivator 2 Nuclear Receptor Coactivator 3 Ovarian Diseases Ovary Adult Adult Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor alpha Estrogen Receptor alpha Female Female

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